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2h6u

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[[Image:2h6u.gif|left|200px]]
 
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==Crystal structure of 5-hydroxyisourate hydrolase (formerly known as TRP, transthyretin related protein)==
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The line below this paragraph, containing "STRUCTURE_2h6u", creates the "Structure Box" on the page.
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<StructureSection load='2h6u' size='340' side='right'caption='[[2h6u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2h6u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H6U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h6u OCA], [https://pdbe.org/2h6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h6u RCSB], [https://www.ebi.ac.uk/pdbsum/2h6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h6u ProSAT]</span></td></tr>
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{{STRUCTURE_2h6u| PDB=2h6u | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HIUH_DANRE HIUH_DANRE] Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/2h6u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h6u ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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During early vertebrate evolution, a duplication event in the gene encoding 5-hydroxyisourate hydrolase (HIUase), a widely distributed enzyme of purine metabolism, gave rise to transthyretin (TTR), a thyroid hormone transporter. We report here on the crystal structure of zebra fish HIUase in two different crystal forms. Despite the phylogenetic distance, this structure compares well with those of newly characterized bacterial HIUases, especially with regard to catalytic regions, which are highly preserved. Comparison with TTR structure reveals a highly conserved scaffold, harbouring distinct functional sites located in the same regions of the two vertebrate proteins. Residues that are differentially conserved in HIUases compared to TTR map in putative catalytic regions occupying significant portions of the two halves of a central channel that transverses the whole TTR protein. The evolution of TTR has been accompanied by remarkable changes of the HIUase active sites that gave rise to a channel open at both ends, thus allowing free access to hormone molecules.
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'''Crystal structure of 5-hydroxyisourate hydrolase (formerly known as TRP, transthyretin related protein)'''
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Structure of zebra fish HIUase: insights into evolution of an enzyme to a hormone transporter.,Zanotti G, Cendron L, Ramazzina I, Folli C, Percudani R, Berni R J Mol Biol. 2006 Oct 13;363(1):1-9. Epub 2006 Aug 2. PMID:16952372<ref>PMID:16952372</ref>
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==Overview==
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During early vertebrate evolution, a duplication event in the gene encoding 5-hydroxyisourate hydrolase (HIUase), a widely distributed enzyme of purine metabolism, gave rise to transthyretin (TTR), a thyroid hormone transporter. We report here on the crystal structure of zebra fish HIUase in two different crystal forms. Despite the phylogenetic distance, this structure compares well with those of newly characterized bacterial HIUases, especially with regard to catalytic regions, which are highly preserved. Comparison with TTR structure reveals a highly conserved scaffold, harbouring distinct functional sites located in the same regions of the two vertebrate proteins. Residues that are differentially conserved in HIUases compared to TTR map in putative catalytic regions occupying significant portions of the two halves of a central channel that transverses the whole TTR protein. The evolution of TTR has been accompanied by remarkable changes of the HIUase active sites that gave rise to a channel open at both ends, thus allowing free access to hormone molecules.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2H6U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6U OCA].
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</div>
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<div class="pdbe-citations 2h6u" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structure of zebra fish HIUase: insights into evolution of an enzyme to a hormone transporter., Zanotti G, Cendron L, Ramazzina I, Folli C, Percudani R, Berni R, J Mol Biol. 2006 Oct 13;363(1):1-9. Epub 2006 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16952372 16952372]
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*[[Transthyretin 3D structures|Transthyretin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Hydroxyisourate hydrolase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Berni R]]
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[[Category: Berni, R.]]
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[[Category: Cendron L]]
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[[Category: Cendron, L.]]
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[[Category: Folli C]]
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[[Category: Folli, C.]]
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[[Category: Percudani R]]
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[[Category: Percudani, R.]]
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[[Category: Ramazzina I]]
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[[Category: Ramazzina, I.]]
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[[Category: Zanotti G]]
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[[Category: Zanotti, G.]]
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[[Category: 5-hydroxyisourate hydrolase]]
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[[Category: Allantoin]]
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[[Category: Trp]]
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[[Category: Uric acid degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 7 08:43:42 2008''
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Current revision

Crystal structure of 5-hydroxyisourate hydrolase (formerly known as TRP, transthyretin related protein)

PDB ID 2h6u

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