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| - | [[Image:2vol.jpg|left|200px]] | + | #REDIRECT [[3zo0]] This PDB entry is obsolete and replaced by 3zo0 |
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| - | The line below this paragraph, containing "STRUCTURE_2vol", creates the "Structure Box" on the page.
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| - | {{STRUCTURE_2vol| PDB=2vol | SCENE= }}
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| - | '''MURINE TRIM21 IN COMPLEX WITH MURINE IGG FC'''
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| - | ==Overview==
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| - | The newly identified tripartite motif (TRIM) family of proteins mediate innate immunity and other critical cellular functions. Here we show that TRIM21, which mediates the autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome, is a previously undescribed IgG receptor with a binding mechanism unlike known mammalian Fcgamma receptors. TRIM21 simultaneously targets conserved hot-spot residues on both Ig domains of the Fc fragment using a PRYSPRY domain with a preformed multisite interface. The binding sites on both TRIM21 and Fc are highly conserved to the extent that the proteins are functionally interchangeable through murine, canine, primate, and human species. Pre-steady-state analysis exposes mechanistic conservation at the level of individual residues, which make the same energetic and kinetic contributions to binding despite varying in sequence. Together, our results reveal that TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.
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| - | ==About this Structure==
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| - | 2VOL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOL OCA].
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| - | ==Reference==
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| - | TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved., Keeble AH, Khan Z, Forster A, James LC, Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6045-50. Epub 2008 Apr 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18420815 18420815]
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| - | [[Category: Mus musculus]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Forster, A.]]
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| - | [[Category: James, L C.]]
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| - | [[Category: Keeble, A H.]]
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| - | [[Category: Khan, Z.]]
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| - | [[Category: B30 2]]
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| - | [[Category: Coiled coil]]
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| - | [[Category: Cytoplasm]]
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| - | [[Category: Dna-binding]]
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| - | [[Category: Fc]]
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| - | [[Category: Immune system]]
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| - | [[Category: Metal-binding]]
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| - | [[Category: Mouse igg]]
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| - | [[Category: Nucleus]]
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| - | [[Category: Polymorphism]]
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| - | [[Category: Pryspry]]
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| - | [[Category: Ribonucleoprotein]]
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| - | [[Category: Rna-binding]]
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| - | [[Category: Ro 52]]
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| - | [[Category: Spry systemic lupus erythematosus]]
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| - | [[Category: Systemic lupus erythematosus]]
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| - | [[Category: Zinc]]
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| - | [[Category: Zinc-finger]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 7 08:54:08 2008''
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