2vl7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2vl7", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Current revision (01:27, 21 November 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2vl7.jpg|left|200px]]
 
-
<!--
+
==Structure of S. tokodaii Xpd4==
-
The line below this paragraph, containing "STRUCTURE_2vl7", creates the "Structure Box" on the page.
+
<StructureSection load='2vl7' size='340' side='right'caption='[[2vl7]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2vl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VL7 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
{{STRUCTURE_2vl7| PDB=2vl7 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl7 OCA], [https://pdbe.org/2vl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2vl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl7 ProSAT]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vl7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vl7 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The XPD helicase (Rad3 in Saccharomyces cerevisiae) is a component of transcription factor IIH (TFIIH), which functions in transcription initiation and Nucleotide Excision Repair in eukaryotes, catalyzing DNA duplex opening localized to the transcription start site or site of DNA damage, respectively. XPD has a 5' to 3' polarity and the helicase activity is dependent on an iron-sulfur cluster binding domain, a feature that is conserved in related helicases such as FancJ. The xpd gene is the target of mutation in patients with xeroderma pigmentosum, trichothiodystrophy, and Cockayne's syndrome, characterized by a wide spectrum of symptoms ranging from cancer susceptibility to neurological and developmental defects. The 2.25 A crystal structure of XPD from the crenarchaeon Sulfolobus tokodaii, presented here together with detailed biochemical analyses, allows a molecular understanding of the structural basis for helicase activity and explains the phenotypes of xpd mutations in humans.
-
'''STRUCTURE OF S. TOKODAII XPD4'''
+
Structure of the DNA repair helicase XPD.,Liu H, Rudolf J, Johnson KA, McMahon SA, Oke M, Carter L, McRobbie AM, Brown SE, Naismith JH, White MF Cell. 2008 May 30;133(5):801-12. PMID:18510925<ref>PMID:18510925</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2vl7" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
2VL7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL7 OCA].
+
*[[Helicase 3D structures|Helicase 3D structures]]
-
[[Category: Single protein]]
+
== References ==
-
[[Category: Sulfolobus tokodaii]]
+
<references/>
-
[[Category: Carter, L G.]]
+
__TOC__
-
[[Category: Johnson, K A.]]
+
</StructureSection>
-
[[Category: Liu, L.]]
+
[[Category: Large Structures]]
-
[[Category: Mcmahon, S A.]]
+
[[Category: Sulfurisphaera tokodaii]]
-
[[Category: Naismith, J H.]]
+
[[Category: Carter LG]]
-
[[Category: Oke, M.]]
+
[[Category: Johnson KA]]
-
[[Category: White, M F.]]
+
[[Category: Liu L]]
-
[[Category: Zawadski, M.]]
+
[[Category: McMahon SA]]
-
[[Category: Helicase]]
+
[[Category: Naismith JH]]
-
[[Category: Unknown function]]
+
[[Category: Oke M]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:26:41 2008''
+
[[Category: White MF]]
 +
[[Category: Zawadski M]]

Current revision

Structure of S. tokodaii Xpd4

PDB ID 2vl7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vl7"
Personal tools