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2z0n

From Proteopedia

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2z0n", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:2z0n.jpg|left|200px]]
 
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==Crystal structure of APPL1-BAR domain==
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The line below this paragraph, containing "STRUCTURE_2z0n", creates the "Structure Box" on the page.
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<StructureSection load='2z0n' size='340' side='right'caption='[[2z0n]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z0n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z0N FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0n OCA], [http://pdbe.org/2z0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z0n RCSB], [http://www.ebi.ac.uk/pdbsum/2z0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0n ProSAT], [http://www.topsan.org/Proteins/RSGI/2z0n TOPSAN]</span></td></tr>
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{{STRUCTURE_2z0n| PDB=2z0n | SCENE= }}
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</table>
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== Function ==
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'''Crystal structure of APPL1-BAR domain'''
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[[http://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2Z0N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0N OCA].
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<jmolCheckbox>
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[[Category: Homo sapiens]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/2z0n_consurf.spt"</scriptWhenChecked>
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[[Category: Single protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Kato-Murayama, M.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Murayama, K.]]
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</jmolCheckbox>
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z0n ConSurf].
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[[Category: Sakamoto, A.]]
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<div style="clear:both"></div>
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[[Category: Shirouzu, M.]]
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== References ==
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[[Category: Yokoyama, S.]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Kato-Murayama, M]]
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[[Category: Murayama, K]]
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[[Category: Structural genomic]]
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[[Category: Sakamoto, A]]
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[[Category: Shirouzu, M]]
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[[Category: Yokoyama, S]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Coiled coil]]
[[Category: Coiled coil]]
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[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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[[Category: Structural genomic]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:28:36 2008''
 

Current revision

Crystal structure of APPL1-BAR domain

PDB ID 2z0n

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