We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1b8w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1b8w" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b8w" /> '''DEFENSIN-LIKE PEPTIDE 1'''<br /> ==Overview...)
Current revision (04:24, 17 October 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1b8w.jpg|left|200px]]<br /><applet load="1b8w" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1b8w" />
 
-
'''DEFENSIN-LIKE PEPTIDE 1'''<br />
 
-
==Overview==
+
==DEFENSIN-LIKE PEPTIDE 1==
-
Three defensin-like peptides (DLPs) were isolated from platypus venom and, sequenced. One of these peptides, DLP-1, was synthesized chemically and, its three-dimensional structure was determined using NMR spectroscopy. The, main structural elements of this 42-residue peptide were an anti-parallel, beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix, spanning residues 10-12. The overall three-dimensional fold is similar to, that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI, (Stichodactyla helianthus neurotoxin I). However, the side chains known to, be functionally important in beta-defensin-12 and ShI are not conserved in, DLP-1, suggesting that it has a different biological function. Consistent, with this contention, we showed that DLP-1 possesses no anti-microbial, properties and has no observable activity on rat dorsal-root-ganglion, sodium-channel currents.
+
<StructureSection load='1b8w' size='340' side='right'caption='[[1b8w]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1b8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B8W FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8w OCA], [https://pdbe.org/1b8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b8w RCSB], [https://www.ebi.ac.uk/pdbsum/1b8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8w ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DLP1_ORNAN DLP1_ORNAN] Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.<ref>PMID:10417345</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents.
-
==About this Structure==
+
Solution structure of a defensin-like peptide from platypus venom.,Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW Biochem J. 1999 Aug 1;341 ( Pt 3):785-94. PMID:10417345<ref>PMID:10417345</ref>
-
1B8W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Solution structure of a defensin-like peptide from platypus venom., Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW, Biochem J. 1999 Aug 1;341 ( Pt 3):785-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10417345 10417345]
+
</div>
 +
<div class="pdbe-citations 1b8w" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Ornithorhynchus anatinus]]
[[Category: Ornithorhynchus anatinus]]
-
[[Category: Single protein]]
+
[[Category: Alewood D]]
-
[[Category: Alewood, D.]]
+
[[Category: Alewood PF]]
-
[[Category: Alewood, P.F.]]
+
[[Category: Fletcher JI]]
-
[[Category: Fletcher, J.I.]]
+
[[Category: Gallagher CH]]
-
[[Category: Gallagher, C.H.]]
+
[[Category: King GF]]
-
[[Category: King, G.F.]]
+
[[Category: Kuchel PW]]
-
[[Category: Kuchel, P.W.]]
+
[[Category: Nicholson GM]]
-
[[Category: Nicholson, G.M.]]
+
[[Category: Simpson RJ]]
-
[[Category: Simpson, R.J.]]
+
[[Category: Smith R]]
-
[[Category: Smith, R.]]
+
[[Category: Sutherland SK]]
-
[[Category: Sutherland, S.K.]]
+
[[Category: Torres AM]]
-
[[Category: Torres, A.M.]]
+
[[Category: Wang X]]
-
[[Category: Wang, X.]]
+
-
[[Category: platypus]]
+
-
[[Category: toxin]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:27:57 2007''
+

Current revision

DEFENSIN-LIKE PEPTIDE 1

PDB ID 1b8w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b8w"
Personal tools