3bzm

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[[Image:3bzm.jpg|left|200px]]
 
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==Crystal Structure of Open form of Menaquinone-Specific Isochorismate Synthase, MenF==
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The line below this paragraph, containing "STRUCTURE_3bzm", creates the "Structure Box" on the page.
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<StructureSection load='3bzm' size='340' side='right'caption='[[3bzm]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BZM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
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{{STRUCTURE_3bzm| PDB=3bzm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bzm OCA], [https://pdbe.org/3bzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bzm RCSB], [https://www.ebi.ac.uk/pdbsum/3bzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bzm ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of Open form of Menaquinone-Specific Isochorismate Synthase, MenF'''
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== Function ==
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[https://www.uniprot.org/uniprot/MENF_ECOLI MENF_ECOLI]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The electron carrier menaquinone is one of many important bacterial metabolites that are derived from the key intermediate chorismic acid. MenF, the first enzyme in the menaquinone pathway, catalyzes the isomerization of chorismate to isochorismate. Here, an improved structure of MenF in a new crystal form is presented. The structure, solved at 2.0 A resolution in complex with magnesium, reveals a well defined closed active site. Existing evidence suggests that the mechanism of the reaction catalyzed by MenF involves nucleophilic attack of a water molecule on the chorismate ring. The structure reveals a well defined water molecule located in an appropriate position for activation by Lys190 and attack on the substrate.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/3bzm_consurf.spt"</scriptWhenChecked>
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3BZM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BZM OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structure of isochorismate synthase in complex with magnesium., Parsons JF, Shi KM, Ladner JE, Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):607-10. Epub 2008, Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18453696 18453696]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bzm ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Isochorismate synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Ladner JE]]
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[[Category: Ladner, J E.]]
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[[Category: Parsons JF]]
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[[Category: Parsons, J F.]]
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[[Category: Shi KM]]
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[[Category: Shi, K M.]]
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[[Category: Chorismate]]
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[[Category: Isochorismate]]
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[[Category: Isomerase]]
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[[Category: Menaquinone]]
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[[Category: Menaquinone biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 21:52:50 2008''
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Current revision

Crystal Structure of Open form of Menaquinone-Specific Isochorismate Synthase, MenF

PDB ID 3bzm

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