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2uyh

From Proteopedia

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2uyh", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:2uyh.jpg|left|200px]]
 
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==HhaI DNA methyltransferase S87Q-Q237S mutant complex with 13mer GCGC- GMGC oligonucleotide and SAH==
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The line below this paragraph, containing "STRUCTURE_2uyh", creates the "Structure Box" on the page.
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<StructureSection load='2uyh' size='340' side='right'caption='[[2uyh]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2uyh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UYH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2uyh| PDB=2uyh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyh OCA], [https://pdbe.org/2uyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uyh RCSB], [https://www.ebi.ac.uk/pdbsum/2uyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uyh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/2uyh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uyh ConSurf].
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<div style="clear:both"></div>
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'''HHAI DNA METHYLTRANSFERASE S87Q-Q237S MUTANT COMPLEX WITH 13MER GCGC-GMGC OLIGONUCLEOTIDE AND SAH'''
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2UYH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYH OCA].
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[[Category: Haemophilus haemolyticus]]
[[Category: Haemophilus haemolyticus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Daujotyte, D.]]
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[[Category: Daujotyte D]]
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[[Category: Grazulis, S.]]
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[[Category: Grazulis S]]
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[[Category: Base flipping]]
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[[Category: Dna methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: Restriction system]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:16:21 2008''
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Current revision

HhaI DNA methyltransferase S87Q-Q237S mutant complex with 13mer GCGC- GMGC oligonucleotide and SAH

PDB ID 2uyh

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