2zcu

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[[Image:2zcu.jpg|left|200px]]
 
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==Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli==
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The line below this paragraph, containing "STRUCTURE_2zcu", creates the "Structure Box" on the page.
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<StructureSection load='2zcu' size='340' side='right'caption='[[2zcu]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
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{{STRUCTURE_2zcu| PDB=2zcu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [https://pdbe.org/2zcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [https://www.ebi.ac.uk/pdbsum/2zcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcu ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli'''
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== Function ==
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[https://www.uniprot.org/uniprot/QOR2_ECOLI QOR2_ECOLI] Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Escherichia coli QOR2 [NAD(P)H-dependent quinone oxidoreductase; a ytfG gene product], which catalyzes two-electron reduction of methyl-1,4-benzoquinone, is a new type of quinone-reducing enzyme with distinct primary sequence and oligomeric conformation from previously known quinone oxidoreductases. The crystal structures of native QOR2 and the QOR2-NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) complex reveal that QOR2 consists of two domains (N-domain and C-domain) resembling those of NmrA, a negative transcriptional regulator that belongs to the short-chain dehydrogenase/reductase family. The N-domain, which adopts the Rossmann fold, provides a platform for NADPH binding, whereas the C-domain, which contains a hydrophobic pocket connected to the NADPH-binding site, appears to play important roles in substrate binding. Asn143 near the NADPH-binding site has been identified to be involved in substrate binding and catalysis from structural and mutational analyses. Moreover, compared with wild-type strain, the qor2-overexpressing strain shows growth retardation and remarkable decrease in several enzymes involved in carbon metabolism, suggesting that QOR2 could play some physiological roles in addition to quinone reduction.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcu_consurf.spt"</scriptWhenChecked>
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2ZCU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli., Kim IK, Yim HS, Kim MK, Kim DW, Kim YM, Cha SS, Kang SO, J Mol Biol. 2008 May 30;379(2):372-84. Epub 2008 Apr 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18455185 18455185]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcu ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: NADPH:quinone reductase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Cha SS]]
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[[Category: Cha, S S.]]
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[[Category: Kang SO]]
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[[Category: Kang, S O.]]
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[[Category: Kim DW]]
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[[Category: Kim, D W.]]
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[[Category: Kim IK]]
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[[Category: Kim, I K.]]
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[[Category: Kim MK]]
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[[Category: Kim, M K.]]
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[[Category: Kim YM]]
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[[Category: Kim, Y M.]]
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[[Category: Yim HS]]
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[[Category: Yim, H S.]]
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[[Category: Alpha-beta sandwich]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:18:07 2008''
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Current revision

Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli

PDB ID 2zcu

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