1bjt

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(New page: 200px<br /><applet load="1bjt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bjt, resolution 2.5&Aring;" /> '''TOPOISOMERASE II RESI...)
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[[Image:1bjt.gif|left|200px]]<br /><applet load="1bjt" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bjt, resolution 2.5&Aring;" />
 
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'''TOPOISOMERASE II RESIDUES 409-1201'''<br />
 
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==Overview==
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==TOPOISOMERASE II RESIDUES 409-1201==
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Type II DNA topoisomerases mediate the passage of one DNA duplex through a, transient break in another, an event essential for chromosome segregation, and cell viability. The active sites of the type II topoisomerase dimer, associate covalently with the DNA break-points and must separate by at, least the width of the second DNA duplex to accommodate transport. A new, structure of the Saccharomyces cerevisiae topoisomerase II DNA-binding and, cleavage core suggests that in addition to conformational changes in the, DNA-opening platform, a dramatic reorganization of accessory domains may, occur during catalysis. These conformational differences have implications, for both the DNA-breaking and duplex-transport events in the topo II, reaction mechanism, suggest a mechanism by which two distinct, drug-resistance loci interact, and illustrate the scope of structural, changes in the cycling of molecular machines.
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<StructureSection load='1bjt' size='340' side='right'caption='[[1bjt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bjt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BJT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bjt OCA], [https://pdbe.org/1bjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bjt RCSB], [https://www.ebi.ac.uk/pdbsum/1bjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bjt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOP2_YEAST TOP2_YEAST] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:9685374</ref> <ref>PMID:23022727</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/1bjt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bjt ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1BJT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Active as [http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BJT OCA].
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10201398 10201398]
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__TOC__
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[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Berger JM]]
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[[Category: Berger, J.M.]]
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[[Category: Bogden CE]]
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[[Category: Bogden, C.E.]]
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[[Category: Fass D]]
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[[Category: Fass, D.]]
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[[Category: dna topology]]
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[[Category: dna-binding]]
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[[Category: quaternary change]]
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[[Category: topoisomerase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:42:24 2007''
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Current revision

TOPOISOMERASE II RESIDUES 409-1201

PDB ID 1bjt

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