2jq0

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[[Image:2jq0.jpg|left|200px]]
 
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==Phylloseptin-1==
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The line below this paragraph, containing "STRUCTURE_2jq0", creates the "Structure Box" on the page.
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<StructureSection load='2jq0' size='340' side='right'caption='[[2jq0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pithecopus_hypochondrialis Pithecopus hypochondrialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQ0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_2jq0| PDB=2jq0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jq0 OCA], [https://pdbe.org/2jq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jq0 RCSB], [https://www.ebi.ac.uk/pdbsum/2jq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jq0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLS1_PITHY PLS1_PITHY] Has antibacterial activity against the Gram-positive bacteria S.aureus and E.faecalis and the Gram-negative bacteria E.coli and P.aeruginosa. No hemolytic activity.<ref>PMID:15752569</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phylloseptins are antimicrobial peptides of 19-20 residues which are found in the skin secretions of the Phyllomedusa frogs that inhabit the tropical forests of South and Central Americas. The peptide sequences of PS-1, -2, and -3 carry an amidated C-terminus and they exhibit 74% sequence homology with major variations of only four residues close to the C-terminus. Here we investigated and compared the structures of the three phylloseptins in detail by CD- and two-dimensional NMR spectroscopies in the presence of phospholipid vesicles or in membrane-mimetic environments. Both CD and NMR spectroscopies reveal a high degree of helicity in the order PS-2&gt;/=PS-1&gt;PS-3, where the differences accumulate at the C-terminus. The conformational variations can be explained by taking into consideration electrostatic interactions of the negative ends of the helix dipoles with potentially cationic residues at positions 17 and 18. Whereas two are present in the sequence of PS-1 and -2 only one is present in PS-3. In conclusion, the antimicrobial phylloseptin peptides adopt alpha-helical conformations in membrane environments which are stabilized by electrostatic interactions of the helix dipole as well as other contributions such hydrophobic and capping interactions.
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'''Phylloseptin-1'''
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Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: The role of charges and hydrogen bonding interactions in stabilizing helix conformations.,Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pilo-Veloso D, Bechinger B Peptides. 2008 Oct;29(10):1633-44. Epub 2008 Jul 4. PMID:18656510<ref>PMID:18656510</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2JQ0 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQ0 OCA].
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<div class="pdbe-citations 2jq0" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Almeida, F C.L.]]
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<references/>
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[[Category: Bechinger, B.]]
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__TOC__
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[[Category: Bemquerer, M P.]]
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</StructureSection>
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[[Category: Cesar, A.]]
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[[Category: Large Structures]]
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[[Category: Moraes, C Mendonca.]]
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[[Category: Pithecopus hypochondrialis]]
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[[Category: Pilo-Veloso, D.]]
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[[Category: Almeida FCL]]
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[[Category: Prates, M V.]]
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[[Category: Bechinger B]]
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[[Category: Resende, J M.]]
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[[Category: Bemquerer MP]]
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[[Category: Valente, A.]]
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[[Category: Cesar A]]
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[[Category: Alpha-helix]]
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[[Category: Mendonca Moraes C]]
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[[Category: Amphipathic character]]
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[[Category: Pilo-Veloso D]]
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[[Category: Antimicrobial protein]]
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[[Category: Prates MV]]
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[[Category: C-terminal carboxyamidation]]
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[[Category: Resende JM]]
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[[Category: Peptide]]
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[[Category: Valente A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:50:19 2008''
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Phylloseptin-1

PDB ID 2jq0

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