2qt5

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[[Image:2qt5.jpg|left|200px]]
 
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==Crystal Structure of GRIP1 PDZ12 in Complex with the Fras1 Peptide==
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The line below this paragraph, containing "STRUCTURE_2qt5", creates the "Structure Box" on the page.
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<StructureSection load='2qt5' size='340' side='right'caption='[[2qt5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qt5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QT5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_2qt5| PDB=2qt5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qt5 OCA], [https://pdbe.org/2qt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qt5 RCSB], [https://www.ebi.ac.uk/pdbsum/2qt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qt5 ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of GRIP1 PDZ12 in Complex with the Fras1 Peptide'''
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== Function ==
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[https://www.uniprot.org/uniprot/GRIP1_RAT GRIP1_RAT] May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.<ref>PMID:9069286</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The scaffold protein GRIP1 (glutamate receptor interacting protein 1) binds to and regulates both the trafficking and membrane organization of a large number of transmembrane proteins. Mutation of GRIP1 in mice displays essentially the same phenotype of the mutations of Fras1 or Frem2, which are the animal models of the human genetic disorder Fraser syndrome. However, the molecular basis governing the interaction between GRIP1 and Fras1/Frem2 is unknown. Here, we show that interaction between Fras1 and GRIP1 requires the first two PDZ domains (PDZ1 and PDZ2) to be connected in tandem, as the folding of PDZ1 strictly depends on the covalent attachment of PDZ2. The crystal structure of GRIP1 PDZ12 in complex with the Fras1 C-terminal peptide reveals that the PDZ12 tandem forms a supramodule in which only the peptide-binding groove of PDZ1 is bound with the Fras1 peptide. The GRIP1 PDZ12/Fras1 peptide complex not only provides a mechanistic explanation of the link between GRIP1 and the Fraser syndrome but may also serve as a foundation for searching for potential mutations in GRIP1 that could lead to the Fraser syndrome.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/2qt5_consurf.spt"</scriptWhenChecked>
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2QT5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QT5 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1., Long J, Wei Z, Feng W, Yu C, Zhao YX, Zhang M, J Mol Biol. 2008 Feb 1;375(5):1457-68. Epub 2007 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18155042 18155042]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qt5 ConSurf].
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[[Category: Protein complex]]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Feng, W.]]
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[[Category: Feng W]]
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[[Category: Long, J.]]
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[[Category: Long J]]
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[[Category: Wei, Z.]]
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[[Category: Wei Z]]
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[[Category: Zhang, M.]]
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[[Category: Zhang M]]
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[[Category: Zhao, Y.]]
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[[Category: Zhao Y]]
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[[Category: Alternative splicing]]
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[[Category: Cell junction]]
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[[Category: Cytoplasm]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Membrane]]
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[[Category: Pdz tandem]]
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[[Category: Pdz-peptide complex]]
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[[Category: Peptide binding protein]]
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[[Category: Postsynaptic cell membrane]]
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[[Category: Protein binding]]
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[[Category: Synapse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:52:08 2008''
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Current revision

Crystal Structure of GRIP1 PDZ12 in Complex with the Fras1 Peptide

PDB ID 2qt5

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