3bq4

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[[Image:3bq4.jpg|left|200px]]
 
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==Crystal Structure of Ad35 fiber knob==
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The line below this paragraph, containing "STRUCTURE_3bq4", creates the "Structure Box" on the page.
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<StructureSection load='3bq4' size='340' side='right'caption='[[3bq4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bq4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_35 Human adenovirus 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BQ4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bq4 OCA], [https://pdbe.org/3bq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bq4 RCSB], [https://www.ebi.ac.uk/pdbsum/3bq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bq4 ProSAT]</span></td></tr>
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{{STRUCTURE_3bq4| PDB=3bq4 | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure of Ad35 fiber knob'''
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[https://www.uniprot.org/uniprot/Q7T925_ADE35 Q7T925_ADE35]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Most subgroup B2 adenoviruses use CD46 as their primary receptor. Recent structural and mutagenesis studies suggested that Ad11 and Ad35 likely engage this receptor in a very similar fashion. However, no comparative studies assessing the cell-associated CD46 binding efficiencies of different Ad fibers have been performed. We solved the crystal structure of Ad35 fiber knob and constructed a model of the fiber knob complexed with CD46. Comparison of our model with that of Ad11-CD46 showed that despite a larger CD46-interacting region in the IJ loop of Ad11, the buried surface area was very similar, suggesting that both fiber knobs might exhibit similar binding. In support of this, cell based competition studies demonstrated almost identical binding efficiencies of Ad11 and Ad35 fibers to cell surface CD46. These findings shed further light on CD46 association by Ad and could impact the selection of novel Ad types for gene transfer.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/3bq4_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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3BQ4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_35 Human adenovirus 35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQ4 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bq4 ConSurf].
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Conservation of fiber structure and CD46 usage by subgroup B2 adenoviruses., Pache L, Venkataraman S, Nemerow GR, Reddy VS, Virology. 2008 Jun 5;375(2):573-9. Epub 2008 Mar 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18336857 18336857]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Human adenovirus 35]]
[[Category: Human adenovirus 35]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Nemerow, G R.]]
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[[Category: Nemerow GR]]
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[[Category: Pache, L.]]
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[[Category: Pache L]]
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[[Category: Reddy, V S.]]
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[[Category: Reddy VS]]
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[[Category: Venkataraman, S.]]
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[[Category: Venkataraman S]]
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[[Category: Fiber knob]]
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[[Category: Trimer]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:54:22 2008''
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Current revision

Crystal Structure of Ad35 fiber knob

PDB ID 3bq4

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