3c2j

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[[Image:3c2j.jpg|left|200px]]
 
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==Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)==
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The line below this paragraph, containing "STRUCTURE_3c2j", creates the "Structure Box" on the page.
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<StructureSection load='3c2j' size='340' side='right'caption='[[3c2j]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3c2j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C2J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GGT:TRIOXACARCIN+A'>GGT</scene></td></tr>
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{{STRUCTURE_3c2j| PDB=3c2j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2j OCA], [https://pdbe.org/3c2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c2j RCSB], [https://www.ebi.ac.uk/pdbsum/3c2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2j ProSAT]</span></td></tr>
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</table>
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'''Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Pfoh R]]
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We report a crystal structure that shows an antibiotic that extracts a nucleobase from a DNA molecule 'caught in the act' after forming a covalent bond but before departing with the base. The structure of trioxacarcin A covalently bound to double-stranded d(AACCGGTT) was determined to 1.78 A resolution by MAD phasing employing brominated oligonucleotides. The DNA-drug complex has a unique structure that combines alkylation (at the N7 position of a guanine), intercalation (on the 3'-side of the alkylated guanine), and base flip-out. An antibiotic-induced flipping-out of a single, nonterminal nucleobase from a DNA duplex was observed for the first time in a crystal structure.
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[[Category: Sheldrick GM]]
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==About this Structure==
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3C2J is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2J OCA].
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==Reference==
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Crystal structure of trioxacarcin A covalently bound to DNA., Pfoh R, Laatsch H, Sheldrick GM, Nucleic Acids Res. 2008 May 3;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18453630 18453630]
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[[Category: Single protein]]
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[[Category: Pfoh, R.]]
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[[Category: Sheldrick, G M.]]
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[[Category: B-dna]]
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[[Category: Base flipping]]
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[[Category: Dna-drug complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:54:35 2008''
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Current revision

Crystal structure analysis of trioxacarcin A covalently bound to d(AACCGGTT)

PDB ID 3c2j

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