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1bvp

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(New page: 200px<br /><applet load="1bvp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bvp, resolution 2.6&Aring;" /> '''THE CRYSTAL STRUCTURE...)
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[[Image:1bvp.gif|left|200px]]<br /><applet load="1bvp" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bvp, resolution 2.6&Aring;" />
 
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'''THE CRYSTAL STRUCTURE OF BLUETONGUE VIRUS VP7'''<br />
 
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==Overview==
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==THE CRYSTAL STRUCTURE OF BLUETONGUE VIRUS VP7==
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Bluetongue virus (BTV), a representative of the orbivirus genus of the, Reoviridae, is considerably larger (at 80 nm across), and structurally, more complex, than any virus for which we have comprehensive structural, information. Orbiviruses infect mammalian hosts through insect vectors and, cause economically important diseases of domesticated animals. They, possess a segmented double-stranded RNA genome within a capsid composed of, four major types of polypeptide chains. An outer layer of VP2 and VP5 is, removed as the virus enters the target cell, to leave an intact core, within the cell. This core is 70 nm across and composed of 780 copies of, VP7 (M(r) 38K) that, as trimers, form 260 'bristly' capsomeres clothing an, inner scaffold constructed from VP3 (M(r) 103K). We report here the, crystal structure of VP7 from BTV serotype 10, which reveals a molecular, architecture not seen previously in viral structural proteins. Each, subunit consists of two domains, one a beta-sandwich, the other a bundle, of alpha-helices, and a short carboxy-terminal arm which might tie trimers, together during capsid formation. A concentration of methionine residues, at the core of the molecule could provide plasticity, relieving structural, mismatches during assembly.
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<StructureSection load='1bvp' size='340' side='right'caption='[[1bvp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bvp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bluetongue_virus_(serotype_10_/_American_isolate) Bluetongue virus (serotype 10 / American isolate)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BVP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bvp OCA], [https://pdbe.org/1bvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bvp RCSB], [https://www.ebi.ac.uk/pdbsum/1bvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bvp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP7_BTV10 VP7_BTV10] The VP7 protein is one of the five proteins (with VP1, VP3, VP4, and VP6) which form the inner capsid of the virus.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/1bvp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bvp ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1BVP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bluetongue_virus_10_(isolate_usa) Bluetongue virus 10 (isolate usa)]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BVP OCA].
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The crystal structure of bluetongue virus VP7., Grimes J, Basak AK, Roy P, Stuart D, Nature. 1995 Jan 12;373(6510):167-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7816101 7816101]
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[[Category: Large Structures]]
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[[Category: Bluetongue virus 10 (isolate usa)]]
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[[Category: Grimes J]]
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[[Category: Single protein]]
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[[Category: Stuart D]]
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[[Category: Grimes, J.]]
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[[Category: Stuart, D.]]
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[[Category: trimer]]
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[[Category: virus]]
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[[Category: vp7]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:57:22 2007''
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Current revision

THE CRYSTAL STRUCTURE OF BLUETONGUE VIRUS VP7

PDB ID 1bvp

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