2qs6

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[[Image:2qs6.jpg|left|200px]]
 
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==Structure of a Hoogsteen antiparallel duplex with extra-helical thymines==
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The line below this paragraph, containing "STRUCTURE_2qs6", creates the "Structure Box" on the page.
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<StructureSection load='2qs6' size='340' side='right'caption='[[2qs6]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qs6]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QS6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qs6 OCA], [https://pdbe.org/2qs6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qs6 RCSB], [https://www.ebi.ac.uk/pdbsum/2qs6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qs6 ProSAT]</span></td></tr>
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{{STRUCTURE_2qs6| PDB=2qs6 | SCENE= }}
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</table>
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__TOC__
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'''Structure of a Hoogsteen antiparallel duplex with extra-helical thymines'''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Campos JL]]
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==Overview==
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[[Category: Gouyette C]]
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We present the crystal structure of the DNA duplex formed by d(ATATATCT). The crystals contain seven stacked antiparallel duplexes in the asymmetric unit with A.T Hoogsteen base pairs. The terminal CT sequences bend over so that the thymines enter the minor groove and form a hydrogen bond with thymine 2 of the complementary strand in the Hoogsteen duplex. Cytosines occupy extra-helical positions; they contribute to the crystal lattice through various kinds of interactions, including a unique CAA triplet. The presence of thymine in the minor groove apparently contributes to the stability of the DNA duplex in the Hoogsteen conformation. These observations open the way toward finding under what conditions the Hoogsteen duplex may be stabilized in vivo. The present crystal structure also confirms the tendency of A.T-rich oligonucleotides to crystallize as long helical stacks of duplexes.
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[[Category: Navaza J]]
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[[Category: Pous J]]
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==About this Structure==
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[[Category: Subirana JA]]
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2QS6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS6 OCA].
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[[Category: Urpi L]]
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==Reference==
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Stabilization by extra-helical thymines of a DNA duplex with Hoogsteen base pairs., Pous J, Urpi L, Subirana JA, Gouyette C, Navaza J, Campos JL, J Am Chem Soc. 2008 May 28;130(21):6755-60. Epub 2008 May 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18447354 18447354]
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[[Category: Single protein]]
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[[Category: Campos, J L.]]
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[[Category: Gouyette, C.]]
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[[Category: Navaza, J.]]
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[[Category: Pous, J.]]
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[[Category: Subirana, J A.]]
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[[Category: Urpi, L.]]
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[[Category: Dna]]
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[[Category: Hoogsteen]]
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[[Category: Oligonucleotide]]
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[[Category: Thymine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:58:45 2008''
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Current revision

Structure of a Hoogsteen antiparallel duplex with extra-helical thymines

PDB ID 2qs6

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