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James D Watson/Proteins Intro
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| - | ==Introduction to proteins==
| + | #REDIRECT [[User:James D Watson/Proteins Intro]] |
| - | This will be the start of an attempt to create a topic based page that could be used in teaching. I will spend more time editing it asap.
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| - | <scene name='James_D_Watson/Proteins_Intro/Ligand_binding_site_ras/1'>Click to see walker motif</scene>
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| - | {{STRUCTURE_5p21 | PDB=5p21 | SCENE= }}
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| - | {{Clear}}
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| - | ==Structural superposition==
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| - | The viewer below shows the structural superposition of the triphosphate conformation of H-ras p21 (PDB entry 5p21) with Gdp-bound human rab21 gtpase (PDB entry 1z0i), the structural superposition was made using the MSDfold(SSM)[http://www.ebi.ac.uk/msd-srv/ssm/ 1] server at the EBI[http://www.ebi.ac.uk 2]. Note that the global fold of these two proteins is almost identical yet their sequence identity is only 29.6% (as determined using FASTA). The ligands bound superpose well and comparison of the ligand binding loops show significant structural similarity.
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| - | <applet load='Image:Ras_superposed.pdb' size='400' frame='true' align='left' />
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Current revision
- REDIRECT User:James D Watson/Proteins Intro
