2rf6

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(New page: '''Unreleased structure''' The entry 2rf6 is ON HOLD until Paper Publication Authors: Koksal, A.C., Cingolani, G. Description: Crystal Structure of the Vaccinia Virus Dual-Specificity ...)
Current revision (11:55, 30 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2rf6 is ON HOLD until Paper Publication
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==Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1==
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<StructureSection load='2rf6' size='340' side='right'caption='[[2rf6]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf6 OCA], [https://pdbe.org/2rf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUSP_VACCW DUSP_VACCW] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:1848923</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rf6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rf6 ConSurf].
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<div style="clear:both"></div>
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Authors: Koksal, A.C., Cingolani, G.
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==See Also==
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
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Description: Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1
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== References ==
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<references/>
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__TOC__
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:48:44 2008''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Vaccinia virus]]
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[[Category: Cingolani G]]
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[[Category: Koksal AC]]

Current revision

Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1

PDB ID 2rf6

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