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2rj2

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(New page: '''Unreleased structure''' The entry 2rj2 is ON HOLD until Paper Publication Authors: Vaijayanthimala, S., Velmurugan, D., Mizushima, T., Yamane, T., Yoshida, Y., Tanaka, K. Descriptio...)
Current revision (12:11, 8 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2rj2 is ON HOLD until Paper Publication
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==Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution==
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<StructureSection load='2rj2' size='340' side='right'caption='[[2rj2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Vaijayanthimala, S., Velmurugan, D., Mizushima, T., Yamane, T., Yoshida, Y., Tanaka, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJ2 FirstGlance]. <br>
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Description: Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rj2 OCA], [https://pdbe.org/2rj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2rj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rj2 ProSAT]</span></td></tr>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 08:49:09 2008''
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FBX2_MOUSE FBX2_MOUSE] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.<ref>PMID:12140560</ref> <ref>PMID:15723043</ref> <ref>PMID:17720138</ref> <ref>PMID:17215248</ref> <ref>PMID:14990996</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rj2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rj2 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Mizushima T]]
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[[Category: Tanaka K]]
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[[Category: Vaijayanthimala S]]
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[[Category: Velmurugan D]]
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[[Category: Yamane T]]
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[[Category: Yoshida Y]]

Current revision

Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution

PDB ID 2rj2

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