2vli
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2vli is ON HOLD until Paper Publication Authors: Macedo, S., Kapp, U., Leiros, I., Hall, D., Mitchell, E. Description: Structure of Deinococcus rad...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Deinococcus radiodurans tunicamycin resistance protein== | |
| + | <StructureSection load='2vli' size='340' side='right'caption='[[2vli]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2vli]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deira Deira]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VLI FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vli OCA], [https://pdbe.org/2vli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vli RCSB], [https://www.ebi.ac.uk/pdbsum/2vli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vli ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vli_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vli ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The open-reading frame (ORF) DR_1419 in the Deinococcus radiodurans genome is annotated as a representative of the wide family of tunicamycin-resistance proteins as identified in a range of bacterial genomes. The D. radiodurans ORF DR_1419 was cloned and expressed; the protein TmrD was crystallized and its X-ray crystal structure was determined to 1.95 A resolution. The structure was determined using single-wavelength anomalous diffraction with selenomethionine-derivatized protein. The refined structure is the first to be reported for a member of the tunicamycin-resistance family. It reveals strong structural similarity to the family of nucleoside monophosphate kinases and to the chloramphenicol phosphotransferase of Streptomyces venezuelae, suggesting that the mode of action is possibly by phosphorylation of tunicamycin. | ||
| - | + | Structure of Deinococcus radiodurans tunicamycin-resistance protein (TmrD), a phosphotransferase.,Kapp U, Macedo S, Hall DR, Leiros I, McSweeney SM, Mitchell E Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):479-86., Epub 2008 May 16. PMID:18540055<ref>PMID:18540055</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2vli" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Deira]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hall, D R]] | ||
| + | [[Category: Kapp, U]] | ||
| + | [[Category: Leiros, I]] | ||
| + | [[Category: Macedo, S]] | ||
| + | [[Category: Mitchell, E]] | ||
| + | [[Category: Phosphotransferase]] | ||
| + | [[Category: Transferase]] | ||
Current revision
Structure of Deinococcus radiodurans tunicamycin resistance protein
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