2zhp
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2zhp is ON HOLD until Paper Publication Authors: Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Nonomura, Y., Osada, H. Descripti...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of bleomycin-binding protein from Streptoalloteichus hindustanus complexed with bleomycin derivative== | |
| - | + | <StructureSection load='2zhp' size='340' side='right'caption='[[2zhp]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2zhp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptoalloteichus_hindustanus Streptoalloteichus hindustanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZHP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BY6:[(2S,3R,4R,5S,6S)-2-[(3R,4R,5R,6R)-2-[(1R,2S)-2-[[6-AMINO-2-[(1S)-3-AMINO-1-[(2,3-DIAMINO-3-OXOPROPYL)AMINO]-3-OXOPROPYL]-5-METHYLPYRIMIDINE-4-CARBONYL]AMINO]-3-[[(2S,3R,4R)-5-[[(2R,3S)-1-[2-[4-[4-[3-[4-(3-AMINOPROPYLAMINO)BUTYLAMINO]PROPYLCARBAMOYL]-1,3-THIAZOL-2-YL]-1,3-THIAZOL-2-YL]ETHYLAMINO]-3-HYDROXY-1-OXOBUTAN-2-YL]AMINO]-3-HYDROXY-4-METHYL-5-OXOPENTAN-2-YL]AMINO]-1-(3H-IMIDAZOL-4-YL)-3-OXOPROPOXY]-4,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-3,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-4-YL]+CARBAMATE'>BY6</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhp OCA], [https://pdbe.org/2zhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zhp RCSB], [https://www.ebi.ac.uk/pdbsum/2zhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zhp ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BLE_STRHI BLE_STRHI] Binding protein with a strong affinity to the bleomycin family of antibiotics. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/2zhp_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zhp ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptoalloteichus hindustanus]] | ||
| + | [[Category: Miyazaki I]] | ||
| + | [[Category: Okumura H]] | ||
| + | [[Category: Osada H]] | ||
| + | [[Category: Simizu S]] | ||
Current revision
Crystal structure of bleomycin-binding protein from Streptoalloteichus hindustanus complexed with bleomycin derivative
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