3cmi

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(New page: '''Unreleased structure''' The entry 3cmi is ON HOLD until Paper Publication Authors: Zhang, W.J.Z., He, Y.X., Yu, J., Zhou, C.Z. Description: Crystal structure of glutathione-dependen...)
Current revision (14:59, 1 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3cmi is ON HOLD until Paper Publication
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==Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae==
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<StructureSection load='3cmi' size='340' side='right'caption='[[3cmi]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3cmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CMI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cmi OCA], [https://pdbe.org/3cmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cmi RCSB], [https://www.ebi.ac.uk/pdbsum/3cmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cmi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GPX3_YEAST GPX3_YEAST] Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYP1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYP1 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598') and a reduced Cys-36 in HYP1/GPX3.<ref>PMID:9315326</ref> <ref>PMID:10480913</ref> <ref>PMID:11445588</ref> <ref>PMID:11875065</ref> <ref>PMID:12437921</ref> <ref>PMID:12517450</ref> <ref>PMID:12743123</ref> <ref>PMID:14556853</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/3cmi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cmi ConSurf].
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<div style="clear:both"></div>
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Authors: Zhang, W.J.Z., He, Y.X., Yu, J., Zhou, C.Z.
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==See Also==
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*[[Glutathione peroxidase|Glutathione peroxidase]]
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Description: Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:32:44 2008''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: He YX]]
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[[Category: Yu J]]
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[[Category: Zhang WJZ]]
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[[Category: Zhou CZ]]

Current revision

Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae

PDB ID 3cmi

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