3cut
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3cut is ON HOLD until Paper Publication Authors: Czifrak, K., Kyritsi, C., Felfoldi, N., Dosca, T., Gergely, P., Chrysina, E.D., Siafaka-Kapadai, A....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of glycogen phosphorylase b in complex with N-(-D-glucopyranosyl)-N'-(2-naphthyl)oxamide== | |
| + | <StructureSection load='3cut' size='340' side='right' caption='[[3cut]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CUT FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=179:N-[(NAPHTHALEN-2-YLAMINO)(OXO)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>179</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cuu|3cuu]], [[3cuv|3cuv]], [[3cuw|3cuw]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cut OCA], [http://pdbe.org/3cut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cut RCSB], [http://www.ebi.ac.uk/pdbsum/3cut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cut ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/3cut_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cut ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Glycogen Phosphorylase|Glycogen Phosphorylase]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Oryctolagus cuniculus]] | |
| - | + | [[Category: Phosphorylase]] | |
| + | [[Category: Chrysina, E D]] | ||
| + | [[Category: Kyritsi, C]] | ||
| + | [[Category: Leonidas, D D]] | ||
| + | [[Category: Oikonomakos, N G]] | ||
| + | [[Category: Zographos, S E]] | ||
| + | [[Category: Allosteric enzyme]] | ||
| + | [[Category: Carbohydrate metabolism]] | ||
| + | [[Category: Catalytic site]] | ||
| + | [[Category: Glycogen metabolism]] | ||
| + | [[Category: Glycogen phosphorylase]] | ||
| + | [[Category: Glycosyltransferase]] | ||
| + | [[Category: Nucleotide-binding]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Pyridoxal phosphate]] | ||
| + | [[Category: Rational inhibitor design]] | ||
| + | [[Category: Transferase]] | ||
Current revision
Crystal structure of glycogen phosphorylase b in complex with N-(-D-glucopyranosyl)-N'-(2-naphthyl)oxamide
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Categories: Oryctolagus cuniculus | Phosphorylase | Chrysina, E D | Kyritsi, C | Leonidas, D D | Oikonomakos, N G | Zographos, S E | Allosteric enzyme | Carbohydrate metabolism | Catalytic site | Glycogen metabolism | Glycogen phosphorylase | Glycosyltransferase | Nucleotide-binding | Phosphoprotein | Pyridoxal phosphate | Rational inhibitor design | Transferase
