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3cxb
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3cxb is ON HOLD until Paper Publication Authors: Huang, Z. Description: Crystal Structure of sifa and skip ''Page seeded by [http://oca.weizmann....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of sifa and skip== | |
| - | + | <StructureSection load='3cxb' size='340' side='right'caption='[[3cxb]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3cxb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxb OCA], [https://pdbe.org/3cxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxb RCSB], [https://www.ebi.ac.uk/pdbsum/3cxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxb ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | '' | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SIFA_SALTY SIFA_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.<ref>PMID:12010459</ref> <ref>PMID:15905402</ref> <ref>PMID:18996344</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxb_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxb ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | ||
| + | [[Category: Chai J]] | ||
| + | [[Category: Huang Z]] | ||
Current revision
Crystal Structure of sifa and skip
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