3csk

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[[Image:3csk.jpg|left|200px]]
 
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==Structure of DPP III from Saccharomyces cerevisiae==
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The line below this paragraph, containing "STRUCTURE_3csk", creates the "Structure Box" on the page.
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<StructureSection load='3csk' size='340' side='right'caption='[[3csk]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3csk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CSK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3csk| PDB=3csk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3csk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3csk OCA], [https://pdbe.org/3csk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3csk RCSB], [https://www.ebi.ac.uk/pdbsum/3csk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3csk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPP3_YEAST DPP3_YEAST]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/3csk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3csk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dipeptidyl-peptidases III (DPP III) are zinc-dependent enzymes that specifically cleave the first two amino acids from the N terminus of different length peptides. In mammals, DPP III is associated with important physiological functions and is a potential biomarker for certain types of cancer. Here, we present the 1.95-A crystal structure of yeast DPP III representing the prototype for the M49 family of metallopeptidases. It shows a novel fold with two domains forming a wide cleft containing the catalytic metal ion. DPP III exhibits no overall similarity to other metallopeptidases, such as thermolysin and neprilysin, but zinc coordination and catalytically important residues are structurally conserved. Substrate recognition is accomplished by a binding site for the N terminus of the peptide at an appropriate distance from the metal center and by a series of conserved arginine residues anchoring the C termini of different length substrates.
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'''Structure of DPP III from Saccharomyces cerevisiae'''
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The first structure of dipeptidyl-peptidase III provides insight into the catalytic mechanism and mode of substrate binding.,Baral PK, Jajcanin-Jozic N, Deller S, Macheroux P, Abramic M, Gruber K J Biol Chem. 2008 Aug 8;283(32):22316-24. Epub 2008 Jun 10. PMID:18550518<ref>PMID:18550518</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3csk" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3CSK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CSK OCA].
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*[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]]
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[[Category: Dipeptidyl-peptidase III]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Abramic M]]
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[[Category: Abramic, M.]]
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[[Category: Baral PK]]
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[[Category: Baral, P K.]]
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[[Category: Deller S]]
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[[Category: Deller, S.]]
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[[Category: Gruber K]]
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[[Category: Gruber, K.]]
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[[Category: Jajcanin N]]
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[[Category: Jajcanin, N.]]
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[[Category: Macheroux P]]
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[[Category: Macheroux, P.]]
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[[Category: Aminodipeptidase]]
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[[Category: Aminopeptidase]]
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[[Category: Cytoplasm]]
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[[Category: Hexxgh-motif]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Protease]]
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[[Category: Zinc]]
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[[Category: Zn-hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:50:14 2008''
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Current revision

Structure of DPP III from Saccharomyces cerevisiae

PDB ID 3csk

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