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3cl3

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[[Image:3cl3.jpg|left|200px]]
 
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==Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome==
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The line below this paragraph, containing "STRUCTURE_3cl3", creates the "Structure Box" on the page.
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<StructureSection load='3cl3' size='340' side='right'caption='[[3cl3]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cl3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl3 OCA], [https://pdbe.org/3cl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl3 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl3 ProSAT]</span></td></tr>
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{{STRUCTURE_3cl3| PDB=3cl3 | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome'''
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[https://www.uniprot.org/uniprot/Q76RF1_HHV8 Q76RF1_HHV8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Key to the pathogenicity of several viruses is activation of the canonical nuclear factor-kappaB (NF-kappaB) transcriptional pathway. Subversion of this tightly regulated mechanism is achieved through the production of host mimetic viral proteins that deregulate the transcription process. One such protein is ks-vFLIP (produced by the Kaposi's sarcoma herpes virus [KSHV]), which associates with IKKgamma, an essential component of the IKK complex or signalosome. This interaction renders the canonical NF-kappaB pathway constitutively active and has been linked to Kaposi's sarcoma and other malignancies. In order to elucidate the molecular basis underpinning ks-vFLIP-induced activation of the IKK signalosome, we have determined the crystal structure of a complex involving a fragment of IKKgamma bound to ks-vFLIP at 3.2 A. In addition to identifying and subsequently probing the ks-vFLIP-IKKgamma interface, we have also investigated the effects of a mutation implicated in the genetic disorder anhydrotic ectodermal dysplasia with immunodeficiency (EDA-ID).
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl3_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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3CL3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL3 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cl3 ConSurf].
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Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome., Bagneris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T, Mol Cell. 2008 Jun 6;30(5):620-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18538660 18538660]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Human herpesvirus 8]]
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[[Category: Human gammaherpesvirus 8]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Ageichik, A V.]]
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[[Category: Ageichik AV]]
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[[Category: Bagneris, C.]]
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[[Category: Bagneris C]]
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[[Category: Barrett, T.]]
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[[Category: Barrett T]]
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[[Category: Boshoff, C.]]
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[[Category: Boshoff C]]
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[[Category: Cronin, N.]]
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[[Category: Cronin N]]
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[[Category: Waksman, G.]]
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[[Category: Waksman G]]
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[[Category: Coiled coil]]
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[[Category: Coiled-coil]]
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[[Category: Cytoplasm]]
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[[Category: Death effector domain]]
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[[Category: Disease mutation]]
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[[Category: Ectodermal dysplasia]]
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[[Category: Host-virus interaction]]
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[[Category: Nucleus]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Viral protein/signaling protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:10:46 2008''
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Current revision

Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome

PDB ID 3cl3

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