2o4f

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[[Image:2o4f.gif|left|200px]]
 
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==Structure of a parallel-stranded guanine tetraplex crystallised with monovalent ions==
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The line below this paragraph, containing "STRUCTURE_2o4f", creates the "Structure Box" on the page.
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<StructureSection load='2o4f' size='340' side='right'caption='[[2o4f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2o4f]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O4F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2o4f| PDB=2o4f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o4f OCA], [https://pdbe.org/2o4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o4f RCSB], [https://www.ebi.ac.uk/pdbsum/2o4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o4f ProSAT]</span></td></tr>
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</table>
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'''Structure of a parallel-stranded guanine tetraplex crystallised with monovalent ions'''
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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A parallel 5'-d(TGGGGT)-3' quadruplex was formed in Na(+) solution and crystallized using lithium sulfate as the main precipitating agent. The X-ray structure was determined to 1.5 A resolution in space group P2(1) by molecular replacement. The asymmetric unit consists of a characteristic motif of two quadruplexes stacked at their 5' ends. All nucleotides are clearly defined in the density and could be positioned. A single bound Li(+) ion is observed at the surface of the column formed by the two joined molecules. Thus, this small alkali metal ion appears to be unsuitable as a replacement for the Na(+) ion in the central channel of G-quartets, unlike K(+) or Tl(+) ions. A well conserved constellation of water molecules is observed in the grooves of the dimeric structure.
A parallel 5'-d(TGGGGT)-3' quadruplex was formed in Na(+) solution and crystallized using lithium sulfate as the main precipitating agent. The X-ray structure was determined to 1.5 A resolution in space group P2(1) by molecular replacement. The asymmetric unit consists of a characteristic motif of two quadruplexes stacked at their 5' ends. All nucleotides are clearly defined in the density and could be positioned. A single bound Li(+) ion is observed at the surface of the column formed by the two joined molecules. Thus, this small alkali metal ion appears to be unsuitable as a replacement for the Na(+) ion in the central channel of G-quartets, unlike K(+) or Tl(+) ions. A well conserved constellation of water molecules is observed in the grooves of the dimeric structure.
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==About this Structure==
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Structure of a d(TGGGGT) quadruplex crystallized in the presence of Li+ ions.,Creze C, Rinaldi B, Haser R, Bouvet P, Gouet P Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):682-8. Epub 2007, May 15. PMID:17505106<ref>PMID:17505106</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4F OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of a d(TGGGGT) quadruplex crystallized in the presence of Li+ ions., Creze C, Rinaldi B, Haser R, Bouvet P, Gouet P, Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):682-8. Epub 2007, May 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17505106 17505106]
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</div>
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[[Category: Bouvet, P.]]
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<div class="pdbe-citations 2o4f" style="background-color:#fffaf0;"></div>
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[[Category: Creze, C.]]
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== References ==
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[[Category: Gouet, P.]]
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<references/>
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[[Category: Haser, R.]]
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__TOC__
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[[Category: Rinaldi, B.]]
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</StructureSection>
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[[Category: Dna]]
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[[Category: Large Structures]]
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[[Category: Parallel-stranded]]
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[[Category: Bouvet P]]
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[[Category: Quadruple helix]]
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[[Category: Creze C]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:16:20 2008''
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[[Category: Gouet P]]
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[[Category: Haser R]]
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[[Category: Rinaldi B]]

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Structure of a parallel-stranded guanine tetraplex crystallised with monovalent ions

PDB ID 2o4f

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