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1cic

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(New page: 200px<br /><applet load="1cic" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cic, resolution 2.5&Aring;" /> '''IDIOTOPE-ANTI-IDIOTOP...)
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[[Image:1cic.jpg|left|200px]]<br /><applet load="1cic" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1cic, resolution 2.5&Aring;" />
 
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'''IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225'''<br />
 
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==Overview==
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==IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225==
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Serologically detected antigenic determinants unique to an antibody or, group of antibodies are called idiotopes. The sum of idiotopes of an, antibody constitute its idiotype. Idiotypes have been intensively studied, following a hypothesis for the self-regulation of the immune system, through a network of idiotype-anti-idiotype interactions. Furthermore, as, antigen and anti-idiotypes can competitively bind to idiotype-positive, antigen-specific antibodies, anti-idiotypes may carry an 'internal image', of the external antigen. Here we describe the structure of the complex, between the monoclonal anti-lysozyme FabD1.3 and the anti-idiotopic, FabE225 at 2.5 A resolution. This complex defines a private idiotope, consisting of 13 amino-acid residues, mainly from the, complementarity-determining regions of D1.3. Seven of these residues make, contacts with the antigen, indicating a significant overlap between, idiotope and antigen-combining site. Idiotopic mimicry of the external, antigen is not achieved at the molecular level in this example.
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<StructureSection load='1cic' size='340' side='right'caption='[[1cic]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1cic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CIC FirstGlance]. <br>
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1CIC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cic OCA], [https://pdbe.org/1cic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cic RCSB], [https://www.ebi.ac.uk/pdbsum/1cic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cic ProSAT]</span></td></tr>
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==Reference==
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</table>
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Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1700305 1700305]
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/1cic_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cic ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Bentley GA]]
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[[Category: Bentley, G.A.]]
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[[Category: anti-idiotope]]
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[[Category: fab complex]]
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[[Category: idiotope]]
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[[Category: immunoglobulin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:28:58 2007''
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Current revision

IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225

PDB ID 1cic

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