Template:STRUCTURE 1j1c

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1j1c, resolution 2.10Å ()

Ligands:

Activity:

Non-specific serine/threonine protein kinase, with EC number 2.7.11.1

Related:

1j1b

Structural annotation:
Resources:	CATH : 1J1Ca02, 1J1Ca01, 1J1Cb02, 1J1Cb01 InterPro : Ipr011009, Ipr002290, Ipr008271, Ipr000719 Pfam : PF00069 SCOP : d1j1ca_, d1j1cb_ UniProt : P49841

Functional annotation:
Cellular component:	cytoplasm nucleus beta-catenin destruction complex
Biological process:	ER overload response positive regulation of protein export from nucleus peptidyl-serine phosphorylation glycogen metabolic process protein amino acid phosphorylation Wnt receptor signaling pathway through beta-catenin intracellular signaling cascade negative regulation of apoptosis Wnt receptor signaling pathway
Molecular function:	nucleotide binding kinase activity transferase activity ATP binding protein binding protein serine/threonine kinase activity NF-kappaB binding glycogen synthase kinase 3 activity protein kinase activity p53 binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/Template:STRUCTURE_1j1c"

@@ Line 1: / Line 1: @@
-{{StructureD
+{{Structure
-|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|1j1c, resolution 2.1&Aring; (<scene name='initialview01'>initial scene</scene>)}}}
+|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1j1c]], [[Resolution|resolution]] 2.10&Aring; (<scene name='initialview01'>default scene</scene>)}}}
 |LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
 |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00220 S_TKc]</span>
 |RELATEDENTRY=[[1j1b|1j1b]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j1c OCA], [http://www.ebi.ac.uk/pdbsum/1j1c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j1c RCSB]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j1c RCSB], [http://www.ebi.ac.uk/pdbsum/1j1c PDBsum]</span>
 |FUNCTION={{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0004674 | text = protein serine/threonine kinase activity}}{{GO|id=GO:0051059 | text = NF-kappaB binding}}{{GO|id=GO:0004696 | text = glycogen synthase kinase 3 activity}}{{GO|id=GO:0004672 | text = protein kinase activity}}{{GO|id=GO:0002039 | text = p53 binding}}
 |PROCESS={{GO|id=GO:0006983 | text = ER overload response}}{{GO|id=GO:0046827 | text = positive regulation of protein export from nucleus}}{{GO|id=GO:0018105 | text = peptidyl-serine phosphorylation}}{{GO|id=GO:0005977 | text = glycogen metabolic process}}{{GO|id=GO:0006468 | text = protein amino acid phosphorylation}}{{GO|id=GO:0060070 | text = Wnt receptor signaling pathway through beta-catenin}}{{GO|id=GO:0007242 | text = intracellular signaling cascade}}{{GO|id=GO:0043066 | text = negative regulation of apoptosis}}{{GO|id=GO:0016055 | text = Wnt receptor signaling pathway}}
 |COMPONENT={{GO|id=GO:0005737 | text = cytoplasm}}{{GO|id=GO:0005634 | text = nucleus}}{{GO|id=GO:0030877 | text = beta-catenin destruction complex}}
 |SARESOURCES=<span class='plainlinks'>CATH : [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1j1cA02 1J1Ca02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1j1cA01 1J1Ca01], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1j1cB02 1J1Cb02], [http://www.cathdb.info/cgi-bin/cath/Domain.pl?domain_id=1j1cB01 1J1Cb01]<br>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR011009 Ipr011009], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR002290 Ipr002290], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR008271 Ipr008271], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000719 Ipr000719]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00069 PF00069]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=90760 d1j1ca_], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=90761 d1j1cb_]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P49841 P49841]</span>
-|FARESOURCES=<span class='plainlinks'>GeneCard : [http://www.genecards.org/cgi-bin/carddisp.pl?id=P49841 P49841]</span>
+|uPDB=1J1C|CONSURF={{!}}-
+{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
+{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
+{{!}} '''Toggle Conservation Colors:'''
+{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
+Rows = identical sequences:
+<jmol>
+<jmolButton>
+<script></script>
+<text>A [x]</text>
+<name>jmb_1j1c_A</name>
+<title>toggle chain A</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
+<jmol>
+<jmolButton>
+<script></script>
+<text>B [x]</text>
+<name>jmb_1j1c_B</name>
+<title>toggle chain B</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
 }}

Template:STRUCTURE 1j1c

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