Template:STRUCTURE 1s8o

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Current revision

1s8o, resolution 2.60Å ()

Ligands:

Gene:

EPHX2 (Homo sapiens)

Activity:

Hydrolase, with EC number and 3.3.2.10 3.3.2.9 and 3.3.2.10

Related:

1vj5

Structural annotation:
Resources:	InterPro : Ipr011945, Ipr005834, Ipr006402, Ipr003089, Ipr005833, Ipr000639, Ipr000073 Pfam : PF00702, PF00561 SCOP : d1s8oa2, d1s8oa1 UniProt : P34913

Functional annotation:
Cellular component:	peroxisome soluble fraction cytosol cytoplasm
Biological process:	oxygen and reactive oxygen species metabolic process cellular calcium ion homeostasis inflammatory response response to toxin metabolic process positive regulation of vasodilation xenobiotic metabolic process drug metabolic process aromatic compound metabolic process aromatic compound catabolic process regulation of blood pressure
Molecular function:	magnesium ion binding catalytic activity epoxide hydrolase activity metal ion binding hydrolase activity protein homodimerization activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/Template:STRUCTURE_1s8o"

@@ Line 1: / Line 1: @@
-{{StructureD
+{{Structure
-|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|1s8o, resolution 2.60&Aring; (<scene name='initialview01'>initial scene</scene>)}}}
+|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1s8o]], [[Resolution|resolution]] 2.60&Aring; (<scene name='initialview01'>default scene</scene>)}}}
 |LIGAND= <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Microsomal_epoxide_hydrolase Microsomal epoxide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.9 3.3.2.9] </span>
+|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.9 and 3.3.2.10 3.3.2.9 and 3.3.2.10] </span>
 |GENE= EPHX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00561 Abhydrolase_1], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2267 PldB], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1011 COG1011]</span>
 |RELATEDENTRY=[[1vj5|1vj5]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8o OCA], [http://www.ebi.ac.uk/pdbsum/1s8o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s8o RCSB]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s8o RCSB], [http://www.ebi.ac.uk/pdbsum/1s8o PDBsum]</span>
 |FUNCTION={{GO|id=GO:0000287 | text = magnesium ion binding}}{{GO|id=GO:0003824 | text = catalytic activity}}{{GO|id=GO:0004301 | text = epoxide hydrolase activity}}{{GO|id=GO:0046872 | text = metal ion binding}}{{GO|id=GO:0016787 | text = hydrolase activity}}{{GO|id=GO:0042803 | text = protein homodimerization activity}}
 |PROCESS={{GO|id=GO:0006800 | text = oxygen and reactive oxygen species metabolic process}}{{GO|id=GO:0006874 | text = cellular calcium ion homeostasis}}{{GO|id=GO:0006954 | text = inflammatory response}}{{GO|id=GO:0009636 | text = response to toxin}}{{GO|id=GO:0008152 | text = metabolic process}}{{GO|id=GO:0045909 | text = positive regulation of vasodilation}}{{GO|id=GO:0006805 | text = xenobiotic metabolic process}}{{GO|id=GO:0017144 | text = drug metabolic process}}{{GO|id=GO:0006725 | text = aromatic compound metabolic process}}{{GO|id=GO:0019439 | text = aromatic compound catabolic process}}{{GO|id=GO:0008217 | text = regulation of blood pressure}}
 |COMPONENT={{GO|id=GO:0005777 | text = peroxisome}}{{GO|id=GO:0005625 | text = soluble fraction}}{{GO|id=GO:0005829 | text = cytosol}}{{GO|id=GO:0005737 | text = cytoplasm}}
 |SARESOURCES=<span class='plainlinks'>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR011945 Ipr011945], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR005834 Ipr005834], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR006402 Ipr006402], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR003089 Ipr003089], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR005833 Ipr005833], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000639 Ipr000639], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000073 Ipr000073]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00702 PF00702], [http://pfam.sanger.ac.uk/family?acc=PF00561 PF00561]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=98737 d1s8oa2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&amp;key=98736 d1s8oa1]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P34913 P34913]</span>
-|FARESOURCES=<span class='plainlinks'>GeneCard : [http://www.genecards.org/cgi-bin/carddisp.pl?id=P34913 P34913]</span>
+|uPDB=1S8O|CONSURF={{!}}-
+{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
+{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
+{{!}} '''Toggle Conservation Colors:'''
+{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
+Rows = identical sequences:
+<jmol>
+<jmolButton>
+<script></script>
+<text>A [x]</text>
+<name>jmb_1s8o_A</name>
+<title>toggle chain A</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
 }}

Template:STRUCTURE 1s8o

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