1con

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(New page: 200px<br /><applet load="1con" size="450" color="white" frame="true" align="right" spinBox="true" caption="1con, resolution 2.0&Aring;" /> '''THE REFINED STRUCTURE...)
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[[Image:1con.gif|left|200px]]<br /><applet load="1con" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1con, resolution 2.0&Aring;" />
 
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'''THE REFINED STRUCTURE OF CADMIUM SUBSTITUTED CONCANAVALIN A AT 2.0 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==THE REFINED STRUCTURE OF CADMIUM SUBSTITUTED CONCANAVALIN A AT 2.0 ANGSTROMS RESOLUTION==
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The three-dimensional structure of cadmium-substituted concanavalin A has, been refined using X-PLOR. The R factor on all data between 8 and 2 A is, 17.1%. The protein crystallizes in space group I222 with cell dimensions a, = 88.7, b = 86.5 and c = 62.5 A and has one protein subunit per asymmetric, unit. The final structure contains 237 amino acids, two Cd ions, one Ca, ion and 144 water molecules. One Cd ion occupies the transition-metal, binding site and the second occupies an additional site, the coordinates, of which were first reported by Weinzierl &amp; Kalb [FEBS Lett. (1971), 18, 268-270]. The additional Cd ion is bound with distorted octahedral, symmetry and bridges the cleft between the two monomers which form the, conventional dimer of concanavalin A. This study provides a detailed, analysis of the refined structure of saccharide-free concanavalin A and is, the basis for comparison with saccharide complexes reported elsewhere.
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<StructureSection load='1con' size='340' side='right'caption='[[1con]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1con]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CON FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1con FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1con OCA], [https://pdbe.org/1con PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1con RCSB], [https://www.ebi.ac.uk/pdbsum/1con PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1con ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CONA_CANEN CONA_CANEN] D-mannose specific lectin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1con_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1con ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1CON is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis] with CD and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CON OCA].
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*[[Concanavalin 3D structures|Concanavalin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Refined structure of cadmium-substituted concanavalin A at 2.0 A resolution., Naismith JH, Habash J, Harrop S, Helliwell JR, Hunter WN, Wan TC, Weisgerber S, Kalb AJ, Yariv J, Acta Crystallogr D Biol Crystallogr. 1993 Nov 1;49(Pt 6):561-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15299493 15299493]
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[[Category: Canavalia ensiformis]]
[[Category: Canavalia ensiformis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gilboa, A.J.Kalb.]]
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[[Category: Habash J]]
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[[Category: Habash, J.]]
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[[Category: Harrop SJ]]
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[[Category: Harrop, S.J.]]
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[[Category: Helliwell JR]]
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[[Category: Helliwell, J.R.]]
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[[Category: Hunter WN]]
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[[Category: Hunter, W.N.]]
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[[Category: Naismith JH]]
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[[Category: Naismith, J.H.]]
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[[Category: Wan TCM]]
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[[Category: Wan, T.C.M.]]
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[[Category: Weisgerber S]]
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[[Category: Weisgerber, S.]]
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[[Category: Yariv J]]
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[[Category: Yariv, J.]]
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[[Category: CA]]
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[[Category: CD]]
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[[Category: lectin(agglutinin)]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:37:48 2007''
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Current revision

THE REFINED STRUCTURE OF CADMIUM SUBSTITUTED CONCANAVALIN A AT 2.0 ANGSTROMS RESOLUTION

PDB ID 1con

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