1coo

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(New page: 200px<br /><applet load="1coo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1coo" /> '''THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE A...)
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[[Image:1coo.gif|left|200px]]<br /><applet load="1coo" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1coo" />
 
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'''THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE ALPHA SUBUNIT'''<br />
 
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==Overview==
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==THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE ALPHA SUBUNIT==
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The structure of the carboxyl-terminal domain of the Escherichia coli RNA, polymerase alpha subunit (alpha CTD), which is regarded as the contact, site for transcription activator proteins and for the promoter UP element, was determined by nuclear magnetic resonance spectroscopy. Its compact, structure of four helices and two long arms enclosing its hydrophobic core, shows a folding topology distinct from those of other DNA-binding, proteins. The UP element binding site was found on the surface comprising, helix 1, the amino-terminal end of helix 4, and the preceding loop., Mutation experiments indicated that the contact sites for transcription, activator proteins are also on the same surface.
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<StructureSection load='1coo' size='340' side='right'caption='[[1coo]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1coo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1coo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coo OCA], [https://pdbe.org/1coo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1coo RCSB], [https://www.ebi.ac.uk/pdbsum/1coo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1coo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1coo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1coo ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1COO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1COO OCA].
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Solution structure of the activator contact domain of the RNA polymerase alpha subunit., Jeon YH, Negishi T, Shirakawa M, Yamazaki T, Fujita N, Ishihama A, Kyogoku Y, Science. 1995 Dec 1;270(5241):1495-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7491496 7491496]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Fujita N]]
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[[Category: Fujita, N.]]
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[[Category: Ishihama A]]
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[[Category: Ishihama, A.]]
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[[Category: Jeon YH]]
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[[Category: Jeon, Y.H.]]
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[[Category: Kyogoku Y]]
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[[Category: Kyogoku, Y.]]
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[[Category: Negishi T]]
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[[Category: Negishi, T.]]
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[[Category: Shirakawa M]]
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[[Category: Shirakawa, M.]]
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[[Category: Yamazaki T]]
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[[Category: Yamazaki, T.]]
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[[Category: transcription regulation]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:37:51 2007''
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Current revision

THE COOH-TERMINAL DOMAIN OF RNA POLYMERASE ALPHA SUBUNIT

PDB ID 1coo

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