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2bsm

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(New page: 200px<br /> <applet load="2bsm" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bsm, resolution 2.05&Aring;" /> '''NOVEL, POTENT SMALL...)
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[[Image:2bsm.gif|left|200px]]<br />
 
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<applet load="2bsm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2bsm, resolution 2.05&Aring;" />
 
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'''NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN'''<br />
 
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==Overview==
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==Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design==
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The crystal structure of a previously reported screening hit 1 (CCT018159), bound to the N terminal domain of molecular chaperone Hsp90 has been used, to design 5-amide analogues. These exhibit enhanced potency against the, target in binding and functional assays with accompanying appropriate, cellular pharmacodynamic changes. Compound 11 (VER-49009) compares, favorably with the clinically evaluated 17-AAG.
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<StructureSection load='2bsm' size='340' side='right'caption='[[2bsm]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BSM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BSM:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE'>BSM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bsm OCA], [https://pdbe.org/2bsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bsm RCSB], [https://www.ebi.ac.uk/pdbsum/2bsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bsm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/2bsm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bsm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG.
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==About this Structure==
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Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.,Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ J Med Chem. 2005 Jun 30;48(13):4212-5. PMID:15974572<ref>PMID:15974572</ref>
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2BSM is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with BSM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BSM OCA]].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design., Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ, J Med Chem. 2005 Jun 30;48(13):4212-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15974572 15974572]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 2bsm" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Barril, X.]]
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[[Category: Brough, P.A.]]
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[[Category: Cansfield, J.E.]]
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[[Category: Drysdale, M.J.]]
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[[Category: Dymock, B.W.]]
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[[Category: Hubbard, R.E.]]
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[[Category: Massey, A.]]
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[[Category: Mcdonald, E.]]
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[[Category: Roughley, S.D.]]
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[[Category: Surgenor, A.]]
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[[Category: Webb, P.]]
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[[Category: Workman, P.]]
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[[Category: Wright, L.]]
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[[Category: BSM]]
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[[Category: atp-binding]]
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[[Category: atpase]]
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[[Category: chaperone]]
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[[Category: heat shock]]
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[[Category: hsp90]]
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[[Category: pu3]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:35:04 2007''
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Barril X]]
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[[Category: Brough PA]]
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[[Category: Cansfield JE]]
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[[Category: Drysdale MJ]]
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[[Category: Dymock BW]]
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[[Category: Hubbard RE]]
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[[Category: Massey A]]
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[[Category: McDonald E]]
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[[Category: Roughley SD]]
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[[Category: Surgenor A]]
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[[Category: Webb P]]
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[[Category: Workman P]]
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[[Category: Wright L]]

Current revision

Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

PDB ID 2bsm

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