1d8a

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(New page: 200px<br /><applet load="1d8a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d8a, resolution 2.2&Aring;" /> '''E. COLI ENOYL REDUCTA...)
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[[Image:1d8a.jpg|left|200px]]<br /><applet load="1d8a" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1d8a, resolution 2.2&Aring;" />
 
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'''E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX'''<br />
 
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==About this Structure==
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==E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX==
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1D8A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NAD and TCL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D8A OCA].
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<StructureSection load='1d8a' size='340' side='right'caption='[[1d8a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1d8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D8A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d8a OCA], [https://pdbe.org/1d8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d8a RCSB], [https://www.ebi.ac.uk/pdbsum/1d8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d8a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/1d8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d8a ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Molecular basis of triclosan activity., Levy CW, Roujeinikova A, Sedelnikova S, Baker PJ, Stuitje AR, Slabas AR, Rice DW, Rafferty JB, Nature. 1999 Apr 1;398(6726):383-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10201369 10201369]
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baker, P.J.]]
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[[Category: Baker PJ]]
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[[Category: Levy, C.W.]]
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[[Category: Levy CW]]
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[[Category: Rafferty, J.B.]]
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[[Category: Rafferty JB]]
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[[Category: Rice, D.W.]]
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[[Category: Rice DW]]
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[[Category: Roujeinikova, A.]]
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[[Category: Roujeinikova A]]
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[[Category: Sedelnikova, S.]]
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[[Category: Sedelnikova S]]
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[[Category: Slabas, A.R.]]
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[[Category: Slabas AR]]
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[[Category: Stuitje, A.R.]]
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[[Category: Stuitje AR]]
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[[Category: NAD]]
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[[Category: TCL]]
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[[Category: e. coli enoyl reductase]]
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[[Category: triclosan]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:04:50 2007''
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Current revision

E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX

PDB ID 1d8a

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