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1prt

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[[Image:1prt.png|left|200px]]
 
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==THE CRYSTAL STRUCTURE OF PERTUSSIS TOXIN==
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The line below this paragraph, containing "STRUCTURE_1prt", creates the "Structure Box" on the page.
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<StructureSection load='1prt' size='340' side='right'caption='[[1prt]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1prt]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. The September 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cholera Toxin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_9 10.2210/rcsb_pdb/mom_2005_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PRT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1prt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1prt OCA], [https://pdbe.org/1prt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1prt RCSB], [https://www.ebi.ac.uk/pdbsum/1prt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1prt ProSAT]</span></td></tr>
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{{STRUCTURE_1prt| PDB=1prt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOX1_BORPE TOX1_BORPE] S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/1prt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1prt ConSurf].
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<div style="clear:both"></div>
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'''THE CRYSTAL STRUCTURE OF PERTUSSIS TOXIN'''
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==See Also==
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*[[Pertussis toxin|Pertussis toxin]]
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__TOC__
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{{ABSTRACT_8075982}}
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</StructureSection>
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==About this Structure==
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1PRT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. The following page contains interesting information on the relation of 1PRT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb69_1.html Cholera Toxin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRT OCA].
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[[Category: Bordetella pertussis]]
[[Category: Bordetella pertussis]]
[[Category: Cholera Toxin]]
[[Category: Cholera Toxin]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Read, R J.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Stein, P E.]]
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[[Category: Read RJ]]
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[[Category: Toxin]]
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[[Category: Stein PE]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:50:05 2008''
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Current revision

THE CRYSTAL STRUCTURE OF PERTUSSIS TOXIN

PDB ID 1prt

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