1di7

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(New page: 200px<br /><applet load="1di7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1di7, resolution 1.60&Aring;" /> '''1.60 ANGSTROM CRYSTA...)
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[[Image:1di7.gif|left|200px]]<br /><applet load="1di7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1di7, resolution 1.60&Aring;" />
 
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'''1.60 ANGSTROM CRYSTAL STRUCTURE OF THE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOGA FROM ESCHERICHIA COLI'''<br />
 
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==Overview==
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==1.60 ANGSTROM CRYSTAL STRUCTURE OF THE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOGA FROM ESCHERICHIA COLI==
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Molybdenum cofactor (Moco) biosynthesis is an evolutionarily conserved, pathway in archaea, eubacteria, and eukaryotes, including humans. Genetic, deficiencies of enzymes involved in this biosynthetic pathway trigger an, autosomal recessive disease with severe neurological symptoms, which, usually leads to death in early childhood. The MogA protein exhibits, affinity for molybdopterin, the organic component of Moco, and has been, proposed to act as a molybdochelatase incorporating molybdenum into Moco., MogA is related to the protein gephyrin, which, in addition to its role in, Moco biosynthesis, is also responsible for anchoring glycinergic receptors, to the cytoskeleton at inhibitory synapses. The high resolution crystal, structure of the Escherichia coli MogA protein has been determined, and it, reveals a trimeric arrangement in which each monomer contains a central, mostly parallel beta-sheet surrounded by alpha-helices on either side., Based on structural and biochemical data, a putative active site was, identified, including two residues that are essential for the catalytic, mechanism.
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<StructureSection load='1di7' size='340' side='right'caption='[[1di7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1di7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DI7 FirstGlance]. <br>
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1DI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DI7 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1di7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1di7 OCA], [https://pdbe.org/1di7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1di7 RCSB], [https://www.ebi.ac.uk/pdbsum/1di7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1di7 ProSAT]</span></td></tr>
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Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli., Liu MT, Wuebbens MM, Rajagopalan KV, Schindelin H, J Biol Chem. 2000 Jan 21;275(3):1814-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10636880 10636880]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MOG_ECOLI MOG_ECOLI] Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor.<ref>PMID:15632135</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/1di7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1di7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Liu, M.T.W.]]
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[[Category: Liu MTW]]
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[[Category: Rajagopalan, K.V.]]
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[[Category: Rajagopalan KV]]
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[[Category: Schindelin, H.]]
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[[Category: Schindelin H]]
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[[Category: Wuebbens, M.M.]]
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[[Category: Wuebbens MM]]
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[[Category: SO4]]
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[[Category: gephyrin]]
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[[Category: moco]]
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[[Category: mog]]
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[[Category: moga]]
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[[Category: molybdenum cofactor]]
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[[Category: moybdenum co-factor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:17:52 2007''
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Current revision

1.60 ANGSTROM CRYSTAL STRUCTURE OF THE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOGA FROM ESCHERICHIA COLI

PDB ID 1di7

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