1thj
From Proteopedia
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- | [[Image:1thj.png|left|200px]] | ||
- | < | + | ==CARBONIC ANHYDRASE FROM METHANOSARCINA== |
- | The | + | <StructureSection load='1thj' size='340' side='right'caption='[[1thj]], [[Resolution|resolution]] 2.80Å' scene=''> |
- | + | == Structural highlights == | |
- | or | + | <table><tr><td colspan='2'>[[1thj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. The January 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Carbonic Anhydrase'' by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_1 10.2210/rcsb_pdb/mom_2004_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1THJ FirstGlance]. <br> |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1thj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1thj OCA], [https://pdbe.org/1thj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1thj RCSB], [https://www.ebi.ac.uk/pdbsum/1thj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1thj ProSAT]</span></td></tr> | |
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/CAH_METTT CAH_METTT] Reversible hydration of carbon dioxide. Important for growth on acetate (PubMed:8041719). As a probably extracellular enzyme, it may support a H(+)/CH(3)COO(-) symport mechanism and/or conversion of CO(2) to HCO(3)(-), removing excess CO(2) produced by growth on acetate (Probable).<ref>PMID:8041719</ref> <ref>PMID:10924115</ref> <ref>PMID:8041719</ref> <ref>PMID:8665839</ref> | ||
+ | == Evolutionary Conservation == | ||
+ | [[Image:Consurf_key_small.gif|200px|right]] | ||
+ | Check<jmol> | ||
+ | <jmolCheckbox> | ||
+ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/th/1thj_consurf.spt"</scriptWhenChecked> | ||
+ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
+ | <text>to colour the structure by Evolutionary Conservation</text> | ||
+ | </jmolCheckbox> | ||
+ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1thj ConSurf]. | ||
+ | <div style="clear:both"></div> | ||
- | + | ==See Also== | |
- | + | *[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]] | |
- | + | == References == | |
- | + | <references/> | |
- | + | __TOC__ | |
- | == | + | </StructureSection> |
- | + | ||
- | + | ||
[[Category: Carbonic Anhydrase]] | [[Category: Carbonic Anhydrase]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Methanosarcina thermophila]] | [[Category: Methanosarcina thermophila]] | ||
- | [[Category: | + | [[Category: RCSB PDB Molecule of the Month]] |
- | [[Category: Kisker | + | [[Category: Kisker C]] |
- | [[Category: Rees | + | [[Category: Rees DC]] |
- | [[Category: Schindelin | + | [[Category: Schindelin H]] |
- | + | ||
- | + | ||
- | + |
Current revision
CARBONIC ANHYDRASE FROM METHANOSARCINA
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