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1dov
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1dov" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dov, resolution 3.00Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1dov.gif|left|200px]]<br /><applet load="1dov" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1dov, resolution 3.00Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF THE ALPHA-CATENIN DIMERIZATION DOMAIN'''<br /> | ||
| - | == | + | ==CRYSTAL STRUCTURE OF THE ALPHA-CATENIN DIMERIZATION DOMAIN== |
| - | + | <StructureSection load='1dov' size='340' side='right'caption='[[1dov]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1dov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DOV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dov OCA], [https://pdbe.org/1dov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dov RCSB], [https://www.ebi.ac.uk/pdbsum/1dov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dov ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CTNA1_MOUSE CTNA1_MOUSE] Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.<ref>PMID:16325583</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/1dov_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dov ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Catenin 3D structures|Catenin 3D structures]] | |
| - | + | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |
| - | == | + | == References == |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Pokutta S]] | |
| - | [[Category: Pokutta | + | [[Category: Weis WI]] |
| - | [[Category: Weis | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF THE ALPHA-CATENIN DIMERIZATION DOMAIN
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