1a7g

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[[Image:1a7g.png|left|200px]]
 
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==THE CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS AT 2.4 ANGSTROMS==
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The line below this paragraph, containing "STRUCTURE_1a7g", creates the "Structure Box" on the page.
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<StructureSection load='1a7g' size='340' side='right'caption='[[1a7g]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1a7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_31 Human papillomavirus 31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A7G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1a7g| PDB=1a7g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7g OCA], [https://pdbe.org/1a7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a7g RCSB], [https://www.ebi.ac.uk/pdbsum/1a7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VE2_HPV31 VE2_HPV31] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/1a7g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a7g ConSurf].
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<div style="clear:both"></div>
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===THE CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS AT 2.4 ANGSTROMS===
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10089498}}, adds the Publication Abstract to the page
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[[Category: Human papillomavirus 31]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10089498 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Bussiere DE]]
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{{ABSTRACT_PUBMED_10089498}}
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[[Category: Giranda VL]]
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==About this Structure==
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1A7G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_31 Human papillomavirus type 31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7G OCA].
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==Reference==
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Structure of the E2 DNA-binding domain from human papillomavirus serotype 31 at 2.4 A., Bussiere DE, Kong X, Egan DA, Walter K, Holzman TF, Lindh F, Robins T, Giranda VL, Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1367-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10089498 10089498]
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[[Category: Human papillomavirus type 31]]
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[[Category: Single protein]]
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[[Category: Bussiere, D E.]]
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[[Category: Giranda, V L.]]
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[[Category: Cervical cancer]]
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[[Category: E2]]
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[[Category: Papillomavirus]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:18:19 2008''
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Current revision

THE CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS AT 2.4 ANGSTROMS

PDB ID 1a7g

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