1a8r

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{{Seed}}
 
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[[Image:1a8r.png|left|200px]]
 
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==GTP CYCLOHYDROLASE I (H112S MUTANT) IN COMPLEX WITH GTP==
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The line below this paragraph, containing "STRUCTURE_1a8r", creates the "Structure Box" on the page.
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<StructureSection load='1a8r' size='340' side='right'caption='[[1a8r]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1a8r]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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{{STRUCTURE_1a8r| PDB=1a8r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8r OCA], [https://pdbe.org/1a8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8r RCSB], [https://www.ebi.ac.uk/pdbsum/1a8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCH1_ECOLI GCH1_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8r ConSurf].
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<div style="clear:both"></div>
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===GTP CYCLOHYDROLASE I (H112S MUTANT) IN COMPLEX WITH GTP===
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==See Also==
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*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12559918}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12559918 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12559918}}
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==About this Structure==
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1A8R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8R OCA].
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==Reference==
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Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I., Rebelo J, Auerbach G, Bader G, Bracher A, Nar H, Hosl C, Schramek N, Kaiser J, Bacher A, Huber R, Fischer M, J Mol Biol. 2003 Feb 14;326(2):503-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12559918 12559918]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: GTP cyclohydrolase I]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Auerbach G]]
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[[Category: Auerbach, G.]]
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[[Category: Bacher A]]
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[[Category: Bacher, A.]]
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[[Category: Bracher A]]
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[[Category: Bracher, A.]]
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[[Category: Huber R]]
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[[Category: Huber, R.]]
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[[Category: Nar H]]
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[[Category: Nar, H.]]
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[[Category: Gtp]]
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[[Category: Hydrolase]]
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[[Category: Pterine synthesis]]
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[[Category: Purine hydrolysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:23:22 2008''
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Current revision

GTP CYCLOHYDROLASE I (H112S MUTANT) IN COMPLEX WITH GTP

PDB ID 1a8r

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