1acf

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{{Seed}}
 
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[[Image:1acf.png|left|200px]]
 
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==ACANTHAMOEBA CASTELLANII PROFILIN IB==
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The line below this paragraph, containing "STRUCTURE_1acf", creates the "Structure Box" on the page.
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<StructureSection load='1acf' size='340' side='right'caption='[[1acf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1acf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ACF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ACF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1acf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1acf OCA], [https://pdbe.org/1acf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1acf RCSB], [https://www.ebi.ac.uk/pdbsum/1acf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1acf ProSAT]</span></td></tr>
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{{STRUCTURE_1acf| PDB=1acf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRO1B_ACACA PRO1B_ACACA] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/1acf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1acf ConSurf].
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<div style="clear:both"></div>
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===ACANTHAMOEBA CASTELLANII PROFILIN IB===
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==See Also==
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*[[Profilin 3D Structures|Profilin 3D Structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8078936}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8078936 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8078936}}
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==About this Structure==
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1ACF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ACF OCA].
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==Reference==
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X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates., Fedorov AA, Magnus KA, Graupe MH, Lattman EE, Pollard TD, Almo SC, Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8636-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8078936 8078936]
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[[Category: Acanthamoeba castellanii]]
[[Category: Acanthamoeba castellanii]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Fedorov, A A.]]
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[[Category: Fedorov AA]]
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[[Category: Graupe, M H.]]
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[[Category: Graupe MH]]
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[[Category: Lattman, E E.]]
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[[Category: Lattman EE]]
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[[Category: Magnus, K A.]]
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[[Category: Magnus KA]]
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[[Category: Pollard, T D.]]
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[[Category: Pollard TD]]
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[[Category: Actin-binding protein]]
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[[Category: Profilin]]
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[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:34:51 2008''
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Current revision

ACANTHAMOEBA CASTELLANII PROFILIN IB

PDB ID 1acf

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