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1aiu

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{{Seed}}
 
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[[Image:1aiu.png|left|200px]]
 
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==HUMAN THIOREDOXIN (D60N MUTANT, REDUCED FORM)==
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The line below this paragraph, containing "STRUCTURE_1aiu", creates the "Structure Box" on the page.
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<StructureSection load='1aiu' size='340' side='right'caption='[[1aiu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1aiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AIU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aiu OCA], [https://pdbe.org/1aiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aiu RCSB], [https://www.ebi.ac.uk/pdbsum/1aiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aiu ProSAT]</span></td></tr>
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{{STRUCTURE_1aiu| PDB=1aiu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/1aiu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aiu ConSurf].
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<div style="clear:both"></div>
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===HUMAN THIOREDOXIN (D60N MUTANT, REDUCED FORM)===
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==See Also==
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9369469}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9369469 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_9369469}}
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==About this Structure==
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1AIU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AIU OCA].
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==Reference==
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Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --&gt; asparagine mutant., Andersen JF, Sanders DA, Gasdaska JR, Weichsel A, Powis G, Montfort WR, Biochemistry. 1997 Nov 18;36(46):13979-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9369469 9369469]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Andersen, J F.]]
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[[Category: Andersen JF]]
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[[Category: Gasdaska, J R.]]
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[[Category: Gasdaska JR]]
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[[Category: Montfort, W R.]]
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[[Category: Montfort WR]]
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[[Category: Powis, G.]]
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[[Category: Powis G]]
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[[Category: Sanders, D A.R.]]
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[[Category: Sanders DAR]]
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[[Category: Weichsel, A.]]
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[[Category: Weichsel A]]
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[[Category: D60n]]
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[[Category: Dimer]]
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[[Category: Electron transport]]
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[[Category: Oxidoreductase]]
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[[Category: Redox-active center]]
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[[Category: Thioredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:56:33 2008''
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Current revision

HUMAN THIOREDOXIN (D60N MUTANT, REDUCED FORM)

PDB ID 1aiu

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