1ako

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{{Seed}}
 
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[[Image:1ako.png|left|200px]]
 
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==EXONUCLEASE III FROM ESCHERICHIA COLI==
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The line below this paragraph, containing "STRUCTURE_1ako", creates the "Structure Box" on the page.
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<StructureSection load='1ako' size='340' side='right'caption='[[1ako]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ako]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ako FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ako OCA], [https://pdbe.org/1ako PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ako RCSB], [https://www.ebi.ac.uk/pdbsum/1ako PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ako ProSAT]</span></td></tr>
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{{STRUCTURE_1ako| PDB=1ako | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EX3_ECOLI EX3_ECOLI] Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/1ako_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ako ConSurf].
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<div style="clear:both"></div>
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===EXONUCLEASE III FROM ESCHERICHIA COLI===
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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*[[Exonuclease 3D structures|Exonuclease 3D structures]]
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_7885481}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 7885481 is the PubMed ID number.
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_7885481}}
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[[Category: Cunningham RP]]
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[[Category: Kuo C-F]]
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==About this Structure==
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[[Category: Mol CD]]
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1AKO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKO OCA].
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[[Category: Tainer JA]]
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[[Category: Thayer MM]]
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==Reference==
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Structure and function of the multifunctional DNA-repair enzyme exonuclease III., Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA, Nature. 1995 Mar 23;374(6520):381-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7885481 7885481]
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[[Category: Escherichia coli]]
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[[Category: Exodeoxyribonuclease III]]
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[[Category: Single protein]]
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[[Category: Cunningham, R P.]]
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[[Category: Kuo, C F.]]
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[[Category: Mol, C D.]]
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[[Category: Tainer, J A.]]
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[[Category: Thayer, M M.]]
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[[Category: Ap-endonuclease]]
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[[Category: Dna repair]]
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[[Category: Exonuclease]]
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[[Category: Nuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:02:49 2008''
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Current revision

EXONUCLEASE III FROM ESCHERICHIA COLI

PDB ID 1ako

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