1dus

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(New page: 200px<br /><applet load="1dus" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dus, resolution 1.80&Aring;" /> '''MJ0882-A hypothetica...)
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[[Image:1dus.gif|left|200px]]<br /><applet load="1dus" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1dus, resolution 1.80&Aring;" />
 
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'''MJ0882-A hypothetical protein from M. jannaschii'''<br />
 
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==Overview==
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==MJ0882-A hypothetical protein from M. jannaschii==
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We have determined the three-dimensional (3-D) structure of protein, MJ0882, which derives from a hypothetical open reading frame in the genome, of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882, at 1.8 A highly resembles that of a methyltransferase, despite limited, sequence similarity to any confirmed methyltransferase. The structure has, an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with, similarities to those commonly found among AdoMet binding proteins., Preliminary biochemical experiments show that MJ0882 specifically binds to, AdoMet, which is the essential co-factor for methyltransferases.
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<StructureSection load='1dus' size='340' side='right'caption='[[1dus]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dus]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DUS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dus OCA], [https://pdbe.org/1dus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dus RCSB], [https://www.ebi.ac.uk/pdbsum/1dus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dus ProSAT], [https://www.topsan.org/Proteins/BSGC/1dus TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y882_METJA Y882_METJA] Probable methyltransferase that uses S-adenosylmethionine as the methyl donor. Binds neither NAD nor NADP in vitro.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/1dus_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dus ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the three-dimensional (3-D) structure of protein MJ0882, which derives from a hypothetical open reading frame in the genome of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882 at 1.8 A highly resembles that of a methyltransferase, despite limited sequence similarity to any confirmed methyltransferase. The structure has an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with similarities to those commonly found among AdoMet binding proteins. Preliminary biochemical experiments show that MJ0882 specifically binds to AdoMet, which is the essential co-factor for methyltransferases.
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==About this Structure==
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Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii.,Huang L, Hung L, Odell M, Yokota H, Kim R, Kim SH J Struct Funct Genomics. 2002;2(3):121-7. PMID:12836702<ref>PMID:12836702</ref>
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1DUS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DUS OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii., Huang L, Hung L, Odell M, Yokota H, Kim R, Kim SH, J Struct Funct Genomics. 2002;2(3):121-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12836702 12836702]
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</div>
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<div class="pdbe-citations 1dus" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Huang L]]
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[[Category: BSGC, Berkeley.Structural.Genomics.Center.]]
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[[Category: Hung L]]
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[[Category: Huang, L.]]
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[[Category: Kim R]]
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[[Category: Hung, L.]]
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[[Category: Kim SH]]
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[[Category: Kim, R.]]
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[[Category: Kim, S.H.]]
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[[Category: berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: hypothetical protein]]
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[[Category: methanococcus jannaschii]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:36:07 2007''
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MJ0882-A hypothetical protein from M. jannaschii

PDB ID 1dus

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