1akx

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{{Seed}}
 
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[[Image:1akx.png|left|200px]]
 
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==HIV-2 TRANS ACTIVATING REGION RNA COMPLEX WITH ARGININAMIDE, NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1akx", creates the "Structure Box" on the page.
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<StructureSection load='1akx' size='340' side='right'caption='[[1akx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1akx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
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{{STRUCTURE_1akx| PDB=1akx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akx OCA], [https://pdbe.org/1akx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akx RCSB], [https://www.ebi.ac.uk/pdbsum/1akx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akx ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The trans-activating region (TAR) RNA-Tat protein interaction is important for activation of transciption in the human immunodeficiency virus (HIV). A model complex for this interaction composed of the two base bulge HIV-2 TAR and the amide derivative of arginine was studied by multidimensional heteronuclear NMR. Because of the improved spectral properties of the HIV-2 TAR complex, a larger number of NOEs in the bulge region were observed than in earlier studies of the HIV-1 TAR-argininamide complex. A total of 681 NOE distance restraints were collected and used to determine the solution structure of the HIV-2 TAR-argininamide complex. As observed in the previously proposed model from this lab, the two A-form stems co-axially stack and the critical U23 and the argininamide are located in the major groove. Model calculations including non-experimental restraints indicate that U23 is within hydrogen bonding distance to A27 consistent with the formation of a U x A x U base-triple. Base-triple formation helps open the major groove to increase the accessibility of G26 to hydrogen bond donors from the guanidinium group of argininamide. Argininamide binding is stabilized by stacking of the guanidinium group between the bases of A22 and U23, forming an argininamide sandwich.
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===HIV-2 TRANS ACTIVATING REGION RNA COMPLEX WITH ARGININAMIDE, NMR, MINIMIZED AVERAGE STRUCTURE===
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Solution structure of the HIV-2 TAR-argininamide complex.,Brodsky AS, Williamson JR J Mol Biol. 1997 Apr 4;267(3):624-39. PMID:9126842<ref>PMID:9126842</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9126842}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1akx" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9126842 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9126842}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKX OCA].
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[[Category: Brodsky AS]]
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[[Category: Williamson JR]]
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==Reference==
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Solution structure of the HIV-2 TAR-argininamide complex., Brodsky AS, Williamson JR, J Mol Biol. 1997 Apr 4;267(3):624-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9126842 9126842]
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[[Category: Brodsky, A S.]]
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[[Category: Williamson, J R.]]
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[[Category: Nmr]]
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[[Category: Protein-rna interaction]]
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[[Category: Transcriptional activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:03:58 2008''
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Current revision

HIV-2 TRANS ACTIVATING REGION RNA COMPLEX WITH ARGININAMIDE, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1akx

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