This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dvi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1dvi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dvi, resolution 2.30&Aring;" /> '''CALPAIN DOMAIN VI WI...)
Current revision (06:59, 7 February 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1dvi.gif|left|200px]]<br /><applet load="1dvi" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1dvi, resolution 2.30&Aring;" />
 
-
'''CALPAIN DOMAIN VI WITH CALCIUM BOUND'''<br />
 
-
==Overview==
+
==CALPAIN DOMAIN VI WITH CALCIUM BOUND==
-
The crystal structure of a Ca(2+)-binding domain (dVI) of rat m-calpain, has been determined at 2.3 A resolution, both with and without bound Ca2+., The structures reveal a unique fold incorporating five EF-hand motifs per, monomer, three of which bind calcium at physiological calcium, concentrations, with one showing a novel EF-hand coordination pattern., This investigation gives us a first view of the calcium-induced, conformational changes, and consequently an insight into the mechanism of, calcium induced activation in calpain. The crystal structures reveal a dVI, homodimer which provides a preliminary model for the subunit dimerization, in calpain.
+
<StructureSection load='1dvi' size='340' side='right'caption='[[1dvi]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1dvi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DVI FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dvi OCA], [https://pdbe.org/1dvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dvi RCSB], [https://www.ebi.ac.uk/pdbsum/1dvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dvi ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CPNS1_RAT CPNS1_RAT] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/1dvi_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dvi ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1DVI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 and 3.4.22.53 3.4.22.52 and 3.4.22.53] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DVI OCA].
+
*[[Calpain 3D structures|Calpain 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes., Blanchard H, Grochulski P, Li Y, Arthur JS, Davies PL, Elce JS, Cygler M, Nat Struct Biol. 1997 Jul;4(7):532-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9228945 9228945]
+
[[Category: Large Structures]]
-
[[Category: Hydrolase]]
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Single protein]]
+
[[Category: Blanchard H]]
-
[[Category: Blanchard, H.]]
+
[[Category: Cygler M]]
-
[[Category: Cygler, M.]]
+
[[Category: Grochulski P]]
-
[[Category: Grochulski, P.]]
+
-
[[Category: CA]]
+
-
[[Category: calcium-dependent protease]]
+
-
[[Category: small subunit]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:37:16 2007''
+

Current revision

CALPAIN DOMAIN VI WITH CALCIUM BOUND

PDB ID 1dvi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dvi"
Personal tools