1ap7

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{{Seed}}
 
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[[Image:1ap7.png|left|200px]]
 
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==P19-INK4D FROM MOUSE, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1ap7", creates the "Structure Box" on the page.
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<StructureSection load='1ap7' size='340' side='right'caption='[[1ap7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ap7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AP7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ap7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ap7 OCA], [https://pdbe.org/1ap7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ap7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ap7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ap7 ProSAT]</span></td></tr>
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{{STRUCTURE_1ap7| PDB=1ap7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDN2D_MOUSE CDN2D_MOUSE] Interacts strongly with CDK4 and CDK6 and inhibits them.<ref>PMID:7739547</ref> <ref>PMID:7739548</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/1ap7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ap7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In cancer, the biochemical pathways that are dominated by the two tumour-suppressor proteins, p53 and Rb, are the most frequently disrupted. Cyclin D-dependent kinases phosphorylate Rb to control its activity and they are, in turn, specifically inhibited by the Ink4 family of cyclin-dependent kinase inhibitors (CDKIs) which cause arrest at the G1 phase of the cell cycle. Mutations in Rb, cyclin D1, its catalytic subunit Cdk4, and the CDKI p16Ink4a, which alter the protein or its level of expression, are all strongly implicated in cancer. This suggests that the Rb 'pathway' is of particular importance. Here we report the structure of the p19Ink4d protein, determined by NMR spectroscopy. The structure indicates that most mutations to the p16Ink4a gene, which result in loss of function, are due to incorrectly folded and/or insoluble proteins. We propose a model for the interaction of Ink4 proteins with D-type cyclin-Cdk4/6 complexes that might provide a basis for the design of therapeutics against cancer. The sequences of the Ink4 family of CDKIs are highly conserved
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===P19-INK4D FROM MOUSE, NMR, 20 STRUCTURES===
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Structure of the cyclin-dependent kinase inhibitor p19Ink4d.,Luh FY, Archer SJ, Domaille PJ, Smith BO, Owen D, Brotherton DH, Raine AR, Xu X, Brizuela L, Brenner SL, Laue ED Nature. 1997 Oct 30;389(6654):999-1003. PMID:9353127<ref>PMID:9353127</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9353127}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ap7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9353127 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9353127}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1AP7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP7 OCA].
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==Reference==
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Structure of the cyclin-dependent kinase inhibitor p19Ink4d., Luh FY, Archer SJ, Domaille PJ, Smith BO, Owen D, Brotherton DH, Raine AR, Xu X, Brizuela L, Brenner SL, Laue ED, Nature. 1997 Oct 30;389(6654):999-1003. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9353127 9353127]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Archer SJ]]
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[[Category: Archer, S J.]]
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[[Category: Domaille PJ]]
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[[Category: Domaille, P J.]]
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[[Category: Laue ED]]
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[[Category: Laue, E D.]]
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[[Category: Luh FY]]
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[[Category: Luh, F Y.]]
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[[Category: Smith BO]]
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[[Category: Smith, B O.]]
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[[Category: Ankyrin repeat]]
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[[Category: Cdki]]
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[[Category: Cell cycle inhibitor]]
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[[Category: Cyclin dependent kinase inhibitor]]
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[[Category: Ink]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:20:23 2008''
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Current revision

P19-INK4D FROM MOUSE, NMR, 20 STRUCTURES

PDB ID 1ap7

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