1ap8

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{{Seed}}
 
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[[Image:1ap8.png|left|200px]]
 
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==TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1ap8", creates the "Structure Box" on the page.
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<StructureSection load='1ap8' size='340' side='right'caption='[[1ap8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ap8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AP8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
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{{STRUCTURE_1ap8| PDB=1ap8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ap8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ap8 OCA], [https://pdbe.org/1ap8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ap8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ap8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ap8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4E_YEAST IF4E_YEAST] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/1ap8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ap8 ConSurf].
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<div style="clear:both"></div>
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===TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9302999}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9302999 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9302999}}
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==About this Structure==
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1AP8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP8 OCA].
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==Reference==
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Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein., Matsuo H, Li H, McGuire AM, Fletcher CM, Gingras AC, Sonenberg N, Wagner G, Nat Struct Biol. 1997 Sep;4(9):717-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9302999 9302999]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Fletcher M]]
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[[Category: Fletcher, M.]]
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[[Category: Gingras AC]]
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[[Category: Gingras, A C.]]
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[[Category: Li H]]
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[[Category: Li, H.]]
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[[Category: Matsuo H]]
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[[Category: Matsuo, H.]]
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[[Category: Mcguire AM]]
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[[Category: Mcguire, A M.]]
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[[Category: Sonenberg N]]
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[[Category: Sonenberg, N.]]
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[[Category: Wagner G]]
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[[Category: Wagner, G.]]
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[[Category: Rna cap]]
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[[Category: Translation initiation factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:20:32 2008''
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Current revision

TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES

PDB ID 1ap8

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