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1aqz

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{{Seed}}
 
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[[Image:1aqz.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC ASPERGILLUS RIBOTOXIN, RESTRICTOCIN==
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The line below this paragraph, containing "STRUCTURE_1aqz", creates the "Structure Box" on the page.
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<StructureSection load='1aqz' size='340' side='right'caption='[[1aqz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1aqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_restrictus Aspergillus restrictus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1aqz| PDB=1aqz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqz OCA], [https://pdbe.org/1aqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqz RCSB], [https://www.ebi.ac.uk/pdbsum/1aqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqz ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC ASPERGILLUS RIBOTOXIN, RESTRICTOCIN===
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== Function ==
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[https://www.uniprot.org/uniprot/RNMG_ASPRE RNMG_ASPRE] This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_8805570}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 8805570 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqz_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_8805570}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1AQZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_restrictus Aspergillus restrictus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQZ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqz ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Insights into specificity of cleavage and mechanism of cell entry from the crystal structure of the highly specific Aspergillus ribotoxin, restrictocin., Yang X, Moffat K, Structure. 1996 Jul 15;4(7):837-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805570 8805570]
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</StructureSection>
[[Category: Aspergillus restrictus]]
[[Category: Aspergillus restrictus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Moffat, K.]]
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[[Category: Moffat K]]
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[[Category: Yang, X.]]
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[[Category: Yang X]]
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[[Category: Cell-entry activity]]
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[[Category: Laue diffraction]]
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[[Category: Protein-rna specific interaction]]
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[[Category: Ribosome-inactivating protein]]
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[[Category: Ribotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:26:40 2008''
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Current revision

CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC ASPERGILLUS RIBOTOXIN, RESTRICTOCIN

PDB ID 1aqz

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