1au6

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[[Image:1au6.png|left|200px]]
 
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==SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1au6", creates the "Structure Box" on the page.
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<StructureSection load='1au6' size='340' side='right'caption='[[1au6]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1au6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AU6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BPT:BIS(TRANS-PLATINUM+ETHYLENEDIAMINE+DIAMINE+CHLORO)COMPLEX'>BPT</scene></td></tr>
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{{STRUCTURE_1au6| PDB=1au6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1au6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1au6 OCA], [https://pdbe.org/1au6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1au6 RCSB], [https://www.ebi.ac.uk/pdbsum/1au6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1au6 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.
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===SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE===
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A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA.,Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126<ref>PMID:7664126</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1au6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 7664126 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7664126}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA].
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[[Category: Farrell N]]
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[[Category: Reedijk J]]
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==Reference==
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[[Category: Van Boom JH]]
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A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA., Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH, Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664126 7664126]
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[[Category: Van Boom SSGE]]
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[[Category: Boom, J H.Van.]]
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[[Category: Wang AH-J]]
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[[Category: Boom, S S.G E.Van.]]
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[[Category: Yang D]]
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[[Category: Farrell, N.]]
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[[Category: Reedijk, J.]]
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[[Category: Wang, A H.J.]]
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[[Category: Yang, D.]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: Dna]]
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[[Category: Dumbbell structure]]
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[[Category: Interstrand crosslink]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:35:59 2008''
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Current revision

SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1au6

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