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1avg

From Proteopedia

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{{Seed}}
 
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[[Image:1avg.png|left|200px]]
 
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==THROMBIN INHIBITOR FROM TRIATOMA PALLIDIPENNIS==
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The line below this paragraph, containing "STRUCTURE_1avg", creates the "Structure Box" on the page.
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<StructureSection load='1avg' size='340' side='right'caption='[[1avg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1avg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Meccus_pallidipennis Meccus pallidipennis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AVG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1avg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1avg OCA], [https://pdbe.org/1avg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1avg RCSB], [https://www.ebi.ac.uk/pdbsum/1avg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1avg ProSAT]</span></td></tr>
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{{STRUCTURE_1avg| PDB=1avg | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/1avg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1avg ConSurf].
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<div style="clear:both"></div>
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===THROMBIN INHIBITOR FROM TRIATOMA PALLIDIPENNIS===
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==See Also==
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*[[Thrombin 3D Structures|Thrombin 3D Structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9342325}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9342325 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9342325}}
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==About this Structure==
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1AVG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Triatoma_pallidipennis Triatoma pallidipennis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVG OCA].
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==Reference==
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Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug., Fuentes-Prior P, Noeske-Jungblut C, Donner P, Schleuning WD, Huber R, Bode W, Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11845-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9342325 9342325]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Thrombin]]
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[[Category: Meccus pallidipennis]]
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[[Category: Triatoma pallidipennis]]
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[[Category: Bode W]]
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[[Category: Bode, W.]]
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[[Category: Fuentes-Prior P]]
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[[Category: Fuentes-Prior, P.]]
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[[Category: Huber R]]
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[[Category: Huber, R.]]
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[[Category: Bovine thrombin]]
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[[Category: Thrombin inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:40:33 2008''
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Current revision

THROMBIN INHIBITOR FROM TRIATOMA PALLIDIPENNIS

PDB ID 1avg

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